Piperazine: Instructions For Use, Dosage And Analogues

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Piperazine: Instructions For Use, Dosage And Analogues
Piperazine: Instructions For Use, Dosage And Analogues
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Piperazine adipate is the basis of the anthelmintic drug Piperazine, which is most often used to treat pinworms in adult patients. The use of the drug is as simple as possible due to the tablet form of release.


  • 1 Pharmacokinetics and pharmacodynamics
  • 2 Indications and contraindications
  • 3 Drug use
  • 4 Side effects and overdose

Pharmacokinetics and pharmacodynamics

Piperazine adipate is most often used for the treatment of enterobiasis and ascariasis. The drug is widely used to treat pinworms in adults. These tablets from worms are characterized by a paralyzing effect on nematodes. Piperazine adipate is able to disrupt the functioning of the neuromuscular system of helminthic invasions, which leads to muscle paralysis and their death.

Removal of worms during the period of use of the drug is carried out in 95 percent of cases. The likelihood of reappearance of helminthic invasions is very small. If Piperazine adipate is used for a repeated course of treatment, then this leads to the complete elimination of helminthic invasions. Piperazine tablets are not capable of destroying ascaris.

Indications and contraindications

Taking a medication should be carried out only if there are indications. The use of the medication is necessary if it suffers from invasions. Piperazine adipate in most cases is prescribed for various types of nematodes, which are parasitic worms. The use of the drug is carried out for the treatment of ascariasis. This disease occurs when the digestive tract is affected by parasitic worms - roundworms. Instructions for the use of Piperazine for children recommends taking it with enterobiasis. With the help of this medication, pinworms can be removed as soon as possible.


Instructions for the use of piperazine adipate contain more detailed information, according to which the drug has a minimum number of contraindications, which allows the drug to be used for the treatment of a wide range of patients.

If a doctor prescribes a drug to a patient, then the doctor should take into account that he is increasing the side effects of chlorpromazine.

Drug use

Before taking Piperazine for worms, it is necessary to determine the presence of allergic reactions to its components. The dose of the drug is determined in accordance with the characteristics of the course of the disease.

If the patient has ascariasis, then he needs to take from 0.5 to 2 grams of the medication. With insufficient effectiveness of Piperazine, the instructions for use allow you to increase the amount of the substance to 3-4 grams, but no more.


Children in the above dosage are allowed to take Piperazine only if they are 13 to 15 years old. At the age of 9 to 12 years, children are advised to take no more than two grams of the drug. The dosage of piperazine adipate for patients aged 3 to 5 years should be 0.5 to 1 gram. If babies from 2 to 3 years old are being treated, then they need to be given from 0.3 to 0.6 grams of the drug. Traditional medicine is allowed for the treatment of children under one year old in a dose of 0.2 to 0.4 grams.

The method of administration of the drug is oral. Instructions for using the medication require drinking it with clean water. Taking the drug from pinworms in adults should be carried out within two weeks, after which you can take a break. If necessary, the course of treatment is repeated.

Can enterobiasis be treated with Piperazine? When this disease appears, it is recommended to take the medicine for people in the same doses as in ascariasis. The duration of therapy should be at least five days.

Since the drug paralyzes the worms, and not removes them, in order to avoid poisoning with decay toxins, it is recommended to regularly put a cleansing enema. To prepare the solution, take boiled water in an amount of 1200 to 1600 milliliters. You need to add soda to it. For each glass of water relies on a teaspoon of soda.

If the patient has ascariasis, then the setting of an enema should be carried out after the end of the course of treatment. Therapy of enterobiasis requires the setting of an enema between courses. If the therapy of enterobiasis continues for a sufficiently long time, then this requires strict adherence to the rules of personal hygiene.

The fairer sex is recommended to use Piperazine during pregnancy. This is due to the fact that analogues of the drug are less safe. The use of the drug can be carried out during the period of breastfeeding of newborns. In this case, for women, the dosage of the traditional medication is the same as for adult patients.

Side effects and overdose

With the wrong medication or the presence of contraindications, patients may experience side effects. In most cases, patients complain of:

  • headache;
  • nausea;
  • vomiting;
  • abdominal pain that is spastic in nature.

If the patient has renal failure, then taking traditional medication can lead to neurotoxic complications. Some patients complain of tremors and muscle weakness.

In case of an overdose of medication, the corresponding symptoms occur. Excessive doses of the medication lead to muscle weakness and tremors. When an overdose occurs, the patient must necessarily wash the stomach, it is recommended to drink activated carbon or other enterosorbents. Doctors in this case prescribe saline laxatives. If the need arises, then patients are prescribed transfusion therapy. When neurological symptoms develop, thiamine administration is recommended.

Despite the high efficacy and safety of the medication, the patient is advised to consult a doctor before using Piperazine, which will ensure the effectiveness of treatment.

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