Niclosamide: Where To Buy, Price, Instructions For Use

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Niclosamide: Where To Buy, Price, Instructions For Use
Niclosamide: Where To Buy, Price, Instructions For Use

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  • Pharmacokinetics

    • With teniarinhoses (infection with bovine tapeworm)
    • With diphyllobothriasis (infection with a wide tapeworm)
    • With hymenolepiasis (infection with dwarf tapeworm)
  • Admission rules
  • Mechanism of action
  • Indications for use
  • Price for Niclosamide
  • Side effects of Fenasal

    • Overdose
    • Side effects
  • You can defeat parasites!

Niclosamide is a chemical known since 1959 that has been used as an anthelminthic agent for the treatment of cestodosis (diseases caused by tapeworms).

It has a detrimental effect on the broad lancet, dwarf and bovine tapeworms and other cestodes. But at the same time, it does not have a special effect in the fight against other types of worms, including round worms (pinworms, ascaris, etc.). It is included in the WHO list of the most important medicines.

What to do in such a situation? To get started, we recommend reading this article. This article details the methods of dealing with parasites. We also recommend contacting a specialist. Read the article >>>

In addition to its use in medicine, niclosamide also belongs to ichthyocides - poisonous agents for fish, which destroy unwanted species in water bodies. In 2016, studies were conducted on the effect of this substance on the Zika virus.

Release form: chewable tablets.

Niclosamide
Niclosamide
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Pharmacokinetics

Niclosamide is effective against intestinal tapeworms that affect humans and animals. It inhibits oxidative phosphorylation in the mitochondria of worms, leading to depletion of energy reserves.

In addition, niclosamide paralyzes the worms during direct contact, and also reduces their resistance to proteolytic enzymes of the gastrointestinal tract. Thanks to the latter, dead worms are partially broken down by the action of gastrointestinal enzymes, and their remains are excreted in feces.

The drug is slightly absorbed from the gastrointestinal tract. The main effect on parasites is in the area of ​​the small and large intestine. Does not undergo metabolism. The half-life of the drug from the human body is 2 to 5 hours.

With teniarinhoses (infection with bovine tapeworm)

For children under 2 years old - 500 mg per day, 5-12 years old - 1 g per day, for children over 12 years old and adults - 2-3 g per day. The duration of admission is determined by a parasitologist depending on the type and severity of the infection.

With diphyllobothriasis (infection with a wide tapeworm)

Adults: 1 g after breakfast and 1 g one hour later.

Children: under 2 years of age - 250 mg after breakfast and 250 mg one hour later; 2-6 years old - 500 mg after breakfast and 500 mg an hour later.

With hymenolepiasis (infection with dwarf tapeworm)

Adults: Initially, 2 g on the first day, followed by 1 g per day for 6 days.

Children: under 2 years old - 500 mg on the first day, followed by 250 mg per day for 6 days; 2-6 years - 1 g on the first day and then 500 mg a day for 6 days.

Admission rules

Taking additional medications (laxatives, other anthelmintics) or taking other measures (diet, fasting, enemas) are not required before, during or immediately after taking niclosamide. The product is taken on an empty stomach (either 1 hour before or 2 hours after a meal) or after a light meal (preferably after breakfast).

The tablets should be chewed or crushed thoroughly and then swallowed with a little water. If niclosamide is given to young children, the tablets are ground into powder and mixed with a little water to form a paste.

Mechanism of action

Niclosamide has the maximum therapeutic effect on tapeworms, especially effective against bovine tapeworm and broad tapeworm. The active ingredient niclosamide prevents the absorption of glucose by parasites, which leads to immobilization of the worms: they stop feeding, slow down their own vital functions, and then leave the body through the intestines along with feces. The latter explains the need to use a laxative together with Niclosamide.

The drug is poorly absorbed in the gastrointestinal tract and excreted through the intestines, partially metabolized. The main effect of the tablets is provided on the small and large intestinal regions. The half-life of the active ingredient from the human body is 2 to 5 hours. Since some people have an intolerance to the substance niclosamide, only a parasitologist is authorized to prescribe the medication.

Indications for use

It is forbidden to carry out treatment with Niclosamide without medical advice, and before prescribing the drug, the specialist performs all the necessary tests to determine the type of helminths.

Before choosing an antiparasitic agent, the doctor takes into account contraindications and possible side effects. So, the pharmacokinetics of tablets provides for their maximum efficacy against bovine tapeworm and the prohibition of treatment with Niclosamide when infected with pork tapeworm (this is indicated in the instructions for use). A positive result of treatment with a remedy can be achieved with:

  • diphyllobothriasis;
  • hymenolepiasis;
  • teniasis;
  • teniarinhoze.

Price for Niclosamide

The drug is produced in the form of tablets on a blister, which are accompanied by detailed instructions for use. However, it is strictly forbidden to start taking antiparasitic drugs without consulting a doctor. You can buy Niclosamide in an online store by ordering delivery by mail, or by visiting a pharmacy. The average cost of pills in Moscow is 150-200 rubles.

Side effects of Fenasal

According to reviews, Fenasal is well tolerated by patients. Side effects are possible in the form of nausea, abdominal pain, dizziness, neurodermatitis, itching of the skin.

Overdose

An overdose of Fenasal according to the instructions causes an increase in its side effects. Vomiting joins with nausea, more pronounced pain sensations appear in the abdominal cavity, rashes of various sizes with severe itching appear on the skin, weakness is felt throughout the body.

If the above symptoms occur, the drug should be discontinued and symptomatic treatment should be carried out.

Side effects

When using medication for cestodosis, the following side effects sometimes occur:

  • nausea;
  • vomiting;
  • indigestion (diarrhea);
  • stomach ache;
  • stomach cramps;
  • decreased or complete lack of appetite;
  • skin reactions (urticaria and others);
  • allergy;
  • increased fatigue;
  • excessive sleepiness;
  • photophobia;
  • swelling;
  • discomfort in the anal area.

If you drink alcoholic beverages during therapy, side effects may become more pronounced.

Some of the above symptoms disappear on their own when the body gets used to the components of the drug. Other side effects may persist until the patient stops taking the medicine.

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