Clostridia Perfringens: Treatment, Diagnosis, What Diseases It Causes, Methods Of Treatment

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Clostridia Perfringens: Treatment, Diagnosis, What Diseases It Causes, Methods Of Treatment
Clostridia Perfringens: Treatment, Diagnosis, What Diseases It Causes, Methods Of Treatment

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  • General information
  • Biological properties
  • What diseases does Clostridia Perfringens cause?
  • Diagnostic and control methods
  • You can defeat parasites!

Clostridia Perfringens is a bacterium that is the causative agent of dangerous human diseases (gas gangrene, foodborne diseases).

At the same time, it lives in the intestinal microflora of a third of healthy people, therefore microbiology considers it as a conditionally pathogenic human microflora and as a sanitary indicative organism.

What to do in such a situation? To get started, we recommend reading this article. This article details the methods of dealing with parasites. We also recommend contacting a specialist. Read the article >>>

General information

Clostridium perfringens was discovered in 1892. It is a gram-positive (strong blue-violet Gram stain), anaerobic spore-forming bacteria.

Clostridia got its name from the Greek word "spindle", since as a result of the formation of spores in the center, it swells and resembles a spindle in shape.

Thanks to this feature, Clostridia Perfringens is able to withstand even boiling and does not respond well to antibiotics.

Clostridia Perfringens
Clostridia Perfringens
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Clostridia Perfringens is subdivided into 6 serotypes, depending on the antigenic properties of the toxins produced by its different species.

They are denoted by Latin letters from A to F and have, depending on the variety, enterotoxic, neurotoxic, necrotic, hemotoxic and other, no less dangerous, effects.

Clostridia Perfringens is a conditionally pathogenic bacillus 4-8 microns long and 0.8-1.5 microns thick, having a small bulge in the middle. The bacterium multiplies by spores. The ideal conditions for its habitat are anaerobic, where there is intense gas formation.

About a hundred of these bacteria are found in 1 g of soil, but not only the soil serves as a habitat for them - it is sewage, and street dust, and feces.

They also feel great in the intestines of humans and animals, both domestic and wild (cows, rabbits, etc.).

Biological properties

Sulfite-reducing clostridia are resistant to heat and cold; even after being in freezers and drying, their viability remains, as well as after other environmental influences (radiation, ultraviolet radiation, exposure to acids, alkalis and disinfectants).

Their spores, caught on food, instantly germinate and infect products: milk, cottage cheese, semi-finished meat products, etc.

The consumption of such infected food products that have not undergone proper heat treatment at high temperatures is dangerous, since the pathogen multiplies very quickly.

At the same time, the pathogenicity factors of the bacteria come into play: various toxins (enterotoxin, necrotoxin, etc.) are released, a huge amount of which is absorbed into the blood and has toxic and necrotic effects on the capillaries, especially the mucous membrane of the small intestine.

General information
General information
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Its results are in the form of hyperemia, edema, multiple hemorrhages, deep necrosis, etc. are found in patients who have died of perfringens clostridiosis caused by this bacterium.

What diseases does Clostridia Perfringens cause?

Clostridia Perfringens causes a whole group of diarrheal diseases, the symptoms of which resemble food poisoning, necrotizing enteritis or pseudomembranous colitis. What it really is will be determined only by clinical and laboratory diagnostics.

The clinical picture of perfringens clostridiosis is as follows. After consuming infected food (most often sausages, dairy products, etc.), vomiting occurs in the interval from 6 to 24 hours, the temperature may rise to 38-39 ° C and other signs of intoxication (decreased appetite, feeling of lethargy and, at the same time, worry); dysfunction of the gastrointestinal tract occurs.

These symptoms are especially pronounced in a child: frequent loose stools mixed with mucus, abdominal pain, sometimes of a spasmodic nature.

As a rule, these symptoms disappear after two to three days, and stool normalization occurs after 4-5 days.

Most children have mild forms of clostridiosis, but there are also severe forms - most often in weakened children with prolonged dysbiosis, for which antibacterial drugs were used.

In severe cases, the onset of the disease looks like an acute infectious gastroenterocolitis: frequent vomiting with bloody impurities, very frequent frothy watery stools (15-20 times a day), often mixed with blood.

Biological properties
Biological properties
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The disease progresses rapidly, causing a sharp deterioration in health (weakness, abdominal pain, dehydration, enlarged liver and spleen, bloating, decreased blood pressure). With dysfunction of the cardiovascular system, a lethal outcome is not excluded.

Serotype A of Clostridium Perfringens, getting on wound surfaces that have not undergone at least primary surgical treatment, on areas of necrosis or tissues that do not receive sufficient blood supply, causes gas (anaerobic) gangrene, in which tissue necrosis rapidly progresses, causing edema, gas formation and severe form of intoxication.

Serotype F of Clostridium Perfringens is capable of causing necrotizing enteritis, with the development of which the tissue of the small intestine is necrotic. The mortality rate is more than 30%.

Diagnostic and control methods

Since the symptomatology of clostridiosis is similar to other intestinal diseases, laboratory diagnostics plays a decisive role in making the diagnosis of intestinal clostridial infection, which allows to detect enterotoxin in feces.

For this purpose, an analysis is carried out for Clostridium Perfringens, for which express methods RIGA and VIEF are used.

Treatment of clostridiosis is carried out mainly with antibacterial drugs and antibiotics: monomycin, gentamicin, tetracycline, furazolidone, ceporin, metronidazole, azithromycin, etc. The dosage depends on age and is prescribed only by the attending physician.

What diseases does Clostridia Perfringens cause?
What diseases does Clostridia Perfringens cause?
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Drug treatment, as a rule, is accompanied by detoxification and symptomatic therapy.

To restore and enhance the body's immunity, you can also supplement herbal treatment from the arsenal of traditional medicine, but an even more important point is the prevention of clostridiosis.

A strong stomach and good immunity are able to resist to some extent its harmful effects, but if the number of bacteria is very large, and the level of immunity is poor, then clostridiosis is likely to develop.

For the prevention of this disease, the main role is played by scrupulous adherence to sanitary rules for the manufacture, storage and sale of food.

It is well known that due to unsatisfactory sanitary and hygienic conditions there is a high risk of contracting intestinal infections, including Clostridia Perfringens.

The child's body is less resistant to such infections, therefore, it is necessary to protect children from carriers of Clostridium Perfringens among the staff of children's institutions and especially catering units.

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