TRICOPOL CANDLES - Instructions For Use, Price, Reviews And Analogues

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TRICOPOL CANDLES - Instructions For Use, Price, Reviews And Analogues
TRICOPOL CANDLES - Instructions For Use, Price, Reviews And Analogues

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How to use Trichopol suppositories correctly against parasitic infections?

Content

  • Release form and composition
  • Pharmacological properties

    • Pharmacodynamics
    • Pharmacokinetics
  • Indications for the use of candles Trichopol
  • Contraindications
  • How to use Trichopol candles
  • Side effects of candles Trichopol
  • Overdose
  • special instructions
  • Application during pregnancy and lactation
  • Drug interactions
  • Analogs
  • Terms and conditions of storage
  • Terms of dispensing from pharmacies
  • Price
  • Reviews

In gynecology, for vaginal infections, Trichopol suppositories are prescribed. The tool belongs to the group of antimicrobial and antiparasitic drugs, has high activity against anaerobic bacteria and protozoan pathogens. It has been used in clinical practice since the middle of the last century.

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In gynecology, for vaginal infections, Trichopol suppositories are prescribed.

Release form and composition

Trichopolum is produced in the form of a cream, gel, solution for infusion, tablets (or suppositories) for oral and vaginal use.

Trichopolum candles are produced in the form of a pessary - a rounded geometric body with a pointed end or in the form of a cylinder tapering upward with an active substance mass of 100 and 500 mg. The color of the dosage form is white or yellowish.

Candles are produced in a cardboard box (outer packaging) of 5-10 pieces. A contoured blister (inner package) made of polymeric materials, sometimes combined with aluminum foil, can have 1-5 cells for placing suppositories.

This dosage form of Trichopolum contains:

  • active ingredient: metronidazole;
  • auxiliary ingredients: cellulose, povidone, crospovidone, silicon dioxide and stearic acid.

For the vaginal forms of Trichopolum, components are selected that have a slight ability to be absorbed through the vaginal mucosa. This enhances the therapeutic effect on the infected areas.

Trichopol candles are produced in a cardboard box (outer packaging) of 5-10 pieces
Trichopol candles are produced in a cardboard box (outer packaging) of 5-10 pieces

Trichopolum candles are produced in a cardboard box (outer packaging) of 5-10 pieces.

This dosage form of Trichopolum contains the active ingredient metronidazole
This dosage form of Trichopolum contains the active ingredient metronidazole

This dosage form of Trichopol contains the active component metronidazole.

One of the auxiliary components of Trichopolum is cellulose
One of the auxiliary components of Trichopolum is cellulose

One of the auxiliary components of Trichopolum is cellulose.

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Pharmacological properties

The effectiveness of Trichopolum, which has antiprotozoal and antibacterial action, in the treatment of Trichomonas infections contributes to the expansion of the scope of its application.

Pharmacodynamics

The mechanism of action of metronidazole, which is a derivative of the 5-nitroimidazole group (highly active broad-spectrum antimicrobial drugs), is based on changes in its own biochemical structure.

Getting inside the cell of pathogenic microorganisms, under the influence of their transport proteins, metronidazole is structurally and dynamically restored to the basic 5-nitro compound.

Metronidazole is active against many strains, but as a vaginal agent it inhibits the reproduction of Trichomonas vaginalis, Entamoeba histolyca, Gardnerella vaginalis, a group of enterotypes Bacteroides spp., Some gram-positive microorganisms: Eubacterium spp., Eubacterium spp., Eubacterium spp., Clocterium spp. dr.

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The active ingredient Trichopolum does not show bactericidal properties in the presence of most aerobic bacteria.

The active ingredient Trichopolum does not show bactericidal properties in the presence of most aerobic bacteria and facultative anaerobes, as well as fungi and viruses. When a mixed pathological flora is detected, it is combined with antibiotics that suppress the process of DNA replication of strains that are insensitive to metronidazole.

Pharmacokinetics

The antibacterial concentration of the drug is found in most tissues and body fluids, including lungs, kidneys, liver, skin, cerebrospinal fluid, vaginal discharge, semen, etc. About 20% of the component binds to serum proteins.

The active substance of Trichopolum suppositories, when introduced into the vagina, is delivered directly to the affected area, without affecting other internal organs. The adsorption of metronidazole in the vaginal mucosa is lower than when using a vaginal gel. This is important to consider to enhance the therapeutic effect. The maximum concentration of the main component when using suppositories is achieved after 1-2 hours.

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Unlike oral administration of Trichopolum, food intake does not affect the pharmacodynamics and pharmacokinetics of suppositories.

Unlike oral administration of Trichopolum, food intake does not affect the pharmacodynamics and pharmacokinetics of suppositories. The transformation process of the drug structure does not slow down.

Indications for the use of candles Trichopol

Trichopolum in the form of suppositories is used to relieve inflammation of various etiologies in the genitourinary sphere: infectious, sexually transmitted infections, associated with a decrease in immunity, hormonal deficiency, premature menopause or poor intimate hygiene.

Vaginal suppositories with metronidazole are indicated for:

  • trichomoniasis;
  • vaginitis;
  • gonorrhea;
  • endometriosis;
  • chlamydia;
  • abdominal infections;
  • cystitis and other diseases of the genitourinary system;
  • inflammation after abortion and gynecological manipulations.
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Vaginal suppositories with metronidazole are indicated for cystitis.

Among the urogenital infections for which Trichopolum is prescribed, Trichomonas vaginitis prevails.

Contraindications

Trichopolum in the form of vaginal suppositories is contraindicated:

  • in case of an allergic reaction to metronidazole or Trichopolum auxiliary components;
  • patients with diseases of the central nervous system, accompanied by severe clinical symptoms;
  • with liver dysfunctions, including age-related;
  • with epilepsy;
  • in the presence of leukopenia, etc.

Only as directed by a doctor, Trichopolum in the form of suppositories is used during pregnancy and is completely excluded during lactation.

How to use Trichopol candles

The decision on the vaginal use of Trichopolum and the dosage is made by the attending physician based on the examination, tests, and the patient's age.

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The decision on the vaginal use of Trichopolum and the dosage is made by the attending physician based on the examination, tests, and the patient's age.

The recommended dose for adults according to the instructions is 5 g (full applicator) twice a day in the morning and in the evening or once at night. The course of treatment is 5-8 days. The duration of therapy prescribed by the doctor must be observed.

After a second examination, an additional course of suppositories is possible, but with a break of 3-4 weeks.

Treatment is started 2-4 days after the end of menstruation. Before the procedure, hands are thoroughly washed with soap. The vaginal suppository is inserted into the vagina in a seated position with the pointed part forward, gently pushing it with a finger to the maximum depth. Doctors recommend pre-moistening suppositories with chilled boiled water.

Side effects of candles Trichopol

With vaginal use of suppositories, it is noted (optional):

  • itching, burning of the mucous membrane of the vagina or vulva;
  • swelling (swelling) of the vulva;
  • the appearance or intensification of mucous secretions;
  • increased urination.
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With vaginal use of suppositories, frequent urination is noted.

Clinical practice indicates the possible appearance of vaginal candidiasis (thrush) after the use of suppositories.

Overdose

Trichopolum in the form of suppositories is a relatively safe drug due to its local use.

But frequent self-treatment can cause side effects. Therapy with vaginal suppositories should not be long and should be carried out no more than 10 days, 2 times a year. In case of an overdose, symptomatic treatment is used.

special instructions

With any dosage form, including suppositories, you should not:

  • Drink alcohol within 48 hours after the last use of Trichopolum.
  • Use the product at risk of leukopenia and neutropenia.
  • Use it in the treatment of children under 7 years of age.
  • Continue intimate relationships if necessary to treat Trichomonas vaginitis.

With trichomoniasis, sexual partners must be treated in parallel. Trichopolum in candles is not used to treat thrush, since it is inert towards fungi.

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With any dosage form of Trichopolum, including suppositories, an intimate relationship should not be continued.

Application during pregnancy and lactation

The active substance of Trichopolum penetrates the placenta and concentrates in the tissues of the fetus. Therefore, suppositories are contraindicated in the first trimester of pregnancy, and in the subsequent are allowed only in the absence of other drugs that are safe for the unborn child. Most experts do not recommend metronidazole suppositories throughout pregnancy.

The use of nitroimidazoles during lactation is prohibited, since they pass into breast milk and accumulate in the child's blood plasma.

Drug interactions

The activity of the active ingredient Trichopolum decreases when interacting with drugs from the group of microsomal liver enzymes and increases with the introduction of inhibitors of these enzymes.

The active substance Trichopolum helps to increase the concentration of lithium in the tissues when interacting with drugs containing this element, which can cause poisoning.

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Care should be taken to use Trichopolum and take immunosuppressants, such as Cyclosporin.

Alcohol-containing drugs should be completely excluded, immunosuppressants, such as Cyclosporin, should be taken with caution.

Analogs

Pharmaceutical analogues of Trichopol suppositories include:

  • vaginal suppositories: Flagil, Metrovagil, Klion-D 100, Orvagil, Trichocept;
  • vaginal gel Metrogyl;
  • vaginal cream Rosamet and other products.

Their action is based on the same structural component for all - metronidazole. But patients should select analogs together with a doctor. It takes into account age, health status, allergic reactions, interaction with medications taken in case of concomitant diseases, etc.

Terms and conditions of storage

Suppositories should be stored for no more than 3 years in a dry, cool place in their original packaging to avoid softening and the appearance of harmful microorganisms on the surface. Candles must be kept out of the reach of children. You can't keep them in the light.

Trichopolum: forms (suppositories and tablets), side effects, more gentle analogs of Klion D

Terms of dispensing from pharmacies

The dispensing of suppositories with metronidazole is carried out by prescription.

Price

The price of Trichopolum in the form of suppositories in most pharmacies ranges from 200 to 330 rubles. Analogs of the drug are cheaper.

Reviews

Angelina, 31 years old, Shchelkovo

I read several reviews about Trichopol candles. There were no enthusiasts. Their authors write that this remedy does not cure anything, and they recommend taking pills, despite the many side effects.

I was diagnosed with bacterial vaginosis, prescribed suppositories. Yes, they are difficult to dissolve. But that's good. They are not absorbed instantly, but slowly affect the problem area. The doctor recommended moistening the candles before use with chilled boiled water.

Maybe the problem of those who did not wait for the effect is the wrong (shallow) candle placement?

In my case, everything ended positively. But each of us has different illnesses, different reactions. It is possible that someone is better off using pills.

Svetlana, 38 years old, Novomoskovsk

I treat cystitis with suppositories and do not quite understand why there are so many unfairly negative reviews. The active substance and its dosage are comparable to those of the tablets. Acts quickly. The form is easy to use. The agent is relatively safe, there is no risk of numerous side effects and harm to internal organs. Inexpensive.

On the recommendation of a doctor, I use 1 candle for 10 days at night. The result is positive.

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