Comparison Of Furazolidone And Enterofuril

2023 Author: Riley Dean | [email protected]. Last modified: 2023-11-27 09:15

Comparison of Furazolidone and Enterofuril

Antibacterial agents are designed to combat infectious diseases of the genitourinary system and gastrointestinal tract. In case of digestive upset, it is necessary to promptly eliminate diarrhea in order to avoid dehydration and restore normal bowel function. Often used are drugs such as Furazolidone or Enterofuril, which are part of the nitrofuran group. Despite the fact that both drugs have antidiarrheal effects, there are differences between them that must be considered.

Furazolidone and Enterofuril are antibacterial agents designed to combat infectious diseases of the genitourinary system and gastrointestinal tract.

Description of Furazolidone

The drug is based on the active synthetic component 5-nitrofurfural, which is active against many strains of protozoan microorganisms and bacteria. Furazolidone has a pronounced antimicrobial, antiprotozoal and immunostimulating effect. It is used in monotherapy, as well as as an additional agent in the treatment of infectious diseases of the gastrointestinal tract, organs of the genitourinary system and skin.

The drug restores healthy microflora and destroys pathogens, stimulates immunity due to the phagocytic activity of leukocytes, and reduces the production of harmful substances and toxins. The therapeutic effect is directly related to the dose used. Thanks to the passage of the full treatment course, it is possible to achieve a destructive effect on bacteria and a general improvement in the patient's condition by reducing the amount of toxins produced by harmful microorganisms.

When taken orally, the drug is absorbed through the gastrointestinal tract, metabolized in the liver, excreted to a greater extent in urine, as well as with feces.

The drug Furazolidone restores healthy microflora.

The use of Furazolidone is advisable in such cases:

• food-type toxicoinfections;
• paratyphoid;
• dysentery of the bacillary form;
• giardiasis;
• infectious diseases of the genitourinary tract;
• burns;
• skin infections.

Contraindications:

• liver disease;
• end-stage chronic renal failure;
• lack of glucose-6-phosphate dehydrogenase;
• individual intolerance to the components of the drug.

Furazolidone is contraindicated in liver diseases.

Furazolidone is not prescribed for pregnant and lactating women. At the time of taking the drug, lactation must be stopped.

In tablet form, it can be used to treat children over 3 years of age.

When taking the drug, side reactions are possible in the form of decreased appetite, nausea, vomiting, allergic rash and itching, neuritis.

Overdose can cause acute toxic hepatitis, neuro- and hematotoxicity. In this case, it is necessary to stop taking the drug and consume large amounts of fluids, B vitamins, antihistamines, and carry out symptomatic therapy.

Furazolidone is taken orally after meals. The standard dosage is 100-150 mg 4 times a day for 5-10 days. The maximum single dose should not exceed 200 mg, daily - 800 mg.

The optimal dosage and duration of the therapeutic course can only be determined by a specialist, taking into account the medical history and individual characteristics of the patient.

Furazolidone is taken orally after meals.

Description Enterofuril

The broad-spectrum antimicrobial agent is active against most infectious agents. Contains 5-nitrofuran. Eliminates diarrhea of various origins, without exerting a systemic effect on the body. It has antibacterial and immunostimulating effects, helps to restore intestinal microflora, eubiosis and prevents the development of superinfection.

The drug disrupts biochemical processes in bacterial cells, preventing the multiplication of harmful microorganisms, and also destroys the cell membrane of microbes, which leads to their death. Enterofuril stimulates the immune system by increasing phagocytosis and does not affect the non-pathogenic intestinal microflora.

When taken orally, 99% of the drug remains in the intestine, where it is metabolized and excreted with feces. The rate of elimination depends on the dose taken and gastrointestinal motility.

Enterofuril is prescribed for such diseases and conditions:

• acute and chronic diarrhea;
• colitis accompanied by chronic diarrhea;
• iatrogenic diarrhea triggered by the intake of antimicrobial drugs;
• chronic and acute diarrhea of unknown etiology.

Enterofuril is prescribed for acute and chronic diarrhea.

It is not used for diarrhea with signs of helminthic invasion.

Contraindications:

• hypersensitivity to the components of the drug;
• children's age up to 1 month.

Enterofuril is not prescribed for infants who were born prematurely. In capsule form, it is not used to treat children under the age of 7 years.

As side effects, allergic reactions are possible in the form of skin rashes, itching, edema, nausea, vomiting, increased diarrhea.

Overdose cases have not been recorded. If the dose is exceeded, symptomatic therapy and gastric lavage are recommended.

Enterofuril is contraindicated in case of hypersensitivity to the drug components.

Enterofuril is not prescribed for children under the age of 1 month.

Allergic reactions in the form of skin rashes can be a side effect of Enterofuril.

Enterofuril is taken orally, regardless of food intake. Adults and children over the age of 15 are prescribed 200 mg 4 times a day. The permissible daily dose is 800 mg. For children over 6 years old, 200 mg 3 times a day is enough. For the treatment of children under the age of 6 years, a suspension is used, the optimal dosage and duration of therapy is determined by the doctor.

Similarity of drugs

The drugs belong to the group of nitrofurans, have antibacterial and antimicrobial effects, block the reproduction of pathogens.

Despite the fact that drugs have a similar effect on the body, it is not recommended to replace each other with them without the knowledge of the doctor, since the drugs have more differences than similarities, and this is important to take into account in order to achieve positive treatment results.

What is the difference between Furazolidone and Enterofuril?

The drugs differ in the active substance. For the production of Furazolidone, a component with the same name is used, which determines its antibacterial and pronounced antiparasitic action. Enterofuril includes nifuroxazide, which is effective in the treatment of infectious processes, diarrhea of an unknown nature and caused by taking medications.

Enterofuril does not destroy non-pathogenic microflora and does not require concomitant intake of probiotics, is not absorbed into the bloodstream and has a local effect, therefore it is more suitable for treating children. The dosage form in the form of a suspension allows you to prescribe the drug even to babies. It is allowed to use the drug during pregnancy as directed by a doctor.

Furazolidone with the bloodstream spreads almost throughout the body, which contributes to a wider list of contraindications and side effects. Therefore, the drug is not recommended for children under 3 years of age, during pregnancy and lactation. For the period of therapy, it is better to exclude alcoholic beverages from the diet, because the use of alcohol together with a drug can provoke nausea, allergic reactions, a drop in blood pressure, and an accelerated heartbeat.

Furazolidone is produced by Russian companies, the manufacturer of Enterofuril is Bosnia and Herzegovina.

What is better Furazolidone or Enterofuril?

For kids

Furazolidone is not prescribed for children under 3 years of age. With giardiasis, the dose of the drug is calculated taking into account the age of the child. Enterofuril in the form of a suspension is used to treat infants from 1 month of age, children over 3 years of age are prescribed the drug in the form of capsules.

With giardiasis, the dose of Furazolidone is calculated taking into account the age of the child.

For adults

Enterofuril has a higher antibacterial activity than Furazolidone, therefore its use is advisable in the development of acute intestinal diseases.

Furazolidone has antiparasitic properties, but it helps to destroy both pathogenic and beneficial intestinal microflora, therefore, it is recommended to use probiotics when using it.

Reviews of doctors

Zinchenko A. V., ENT doctor with 9 years of experience, Omsk: “Enterofuril is a high-quality drug with a wide spectrum of action. A must have in every home medicine cabinet. Can be used to treat infants, pregnant and lactating women. Not an antibiotic, but copes with infections, is not absorbed from the gastrointestinal tract. Convenient to use. Has a high price, but fully justifies it."

Iskorostinsky E. V., urologist with 20 years of experience, Ph. D., Moscow: “Furazolidone is an effective and easy-to-use antimicrobial drug, copes with gastrointestinal tract infections, should be in the home medicine cabinet for diarrhea and food toxicoinfections, the effect appears quickly. I use it in my practice to treat intestinal disorders and infectious diseases. I would like to note the presence of analogues that contain the same active ingredient, but are cheaper."

Patient reviews about Furazolidone and Enterofuril

Ivanova Ya., 28 years old, Yekaterinburg: “I have known Furazolidone since childhood, I drink it for intestinal disorders. I like to eat deliciously, but the intestines are weak and often suffer from diarrhea. The drug is effective - just take a pill and you can forget about the problem. Convenient to take with you, inexpensive. There were no side effects. I recommend it to everyone who has difficulties of this nature."

Masha M., 35 years old, Reutov: “I keep Enterofuril at home in my first-aid kit, I take it with me on the road. I go to work by public transport and often come across rotavirus infection. At the first symptoms I use this drug. If we go to the sea with the whole family, we also always take this product with us."

Yulia K., 31 years old, Yalutorovsk: “Enterofuril was prescribed to the child by a pediatrician for the treatment of diarrhea caused by taking antibiotics. The drug was effective. Used for 5 days, noticeable improvements were noticed after 2 days. The drug caused a slight allergy in the form of skin rashes, but after its removal from the body, everything went away."