GELMADOL - Instructions For Use, Price, Reviews And Analogues

2023 Author: Riley Dean | [email protected]. Last modified: 2023-11-27 09:15

Anthelmintic agent Gelmadol

Content

• 1 Composition and form of release
• 2 Properties
• 3 Indications

• 4 Contraindications

  4.1 With care

• 5 Gelmadol - instructions for use
• 6 Adverse reactions
• 7 Overdose
• 8 Gelmadol during pregnancy
• 9 Special instructions
• 10 Interaction
• 11 Influence on ability to drive vehicles
• 12 Gelmadol: analogues
• 13 Gelmadol Reviews

Helmadol is an anthelmintic agent that effectively fights against a variety of parasites. There is often confusion between Helmadol and Helmadol VM. They are essentially the same drug. The only difference is in the name. Even the manufacturing company is the same. VM in the second case means an abbreviation for "World Medicine". The first one is intended for sale in Belarus, Ukraine and Kazakhstan, the second one goes on sale in Russia. The only significant difference is that the second drug is available only in tablets, while the first is also in the form of a suspension. Otherwise, they are absolutely identical.

Composition and form of release

Release form Gelmadol

At the heart of Gelmadol is a substance like albendazole, which is an anthelmintic substance that underlies many drugs of a similar orientation.

Gelmadol is available only in tablets with a dosage of 200 mg of active substance in each. In addition to the main component, it also has auxiliary ones that help better assimilation of the main ingredient.

Properties

How to cleanse the body of parasites

The main component determined the main functions of the drug:

• Penetrates into the intestines of helminths, where it binds to proteins by tubulins, damaging them and creating an obstacle to the implementation of its main task - the formation of microtubules required for the migration of particles in cells;
• As a result of protein damage, glucose and fumarate reductose, which are the basis for the suppression of cell division at the stage of metamorphosis, lose their ability to transport, the ability to lay eggs and develop larvae is suppressed;
• Due to the blockage of substances vital for helminths, which are the source of their energy, their ability to move is lost.

Helmadol works effectively against most intestinal parasites, both adults and their larvae. Doesn't work against eggs. As an anthelmintic drug, it has a fairly wide spectrum of action.

After taking the drug, absorption occurs in the gastrointestinal tract. It is very poorly absorbed, only 5 percent of the total dose. When combined with fatty foods, this volume increases almost fivefold, which can provoke an overdose or a number of adverse reactions.

There is a double metabolic process. Primary occurs in the liver, where albendazole is converted to albendazole sulfoxide, which is a potent anthelmintic agent. The maximum concentration of a substance in the blood occurs 2-5 hours after it enters the body. Two-thirds binds to plasma proteins and is well distributed in the body, penetrating into many organs and fluids.

After that, a second stage of metabolism takes place. Albendazole sulfoxide is converted to albendazole sulfone. The half-life of this drug occurs after 8-12 hours. In an insignificant amount, it is excreted along with urine. Most of the drug is excreted through the intestines along with the remains of waste products.

In the case of existing liver diseases, the volume of bioavailability increases and the content of the active substance in the blood doubles. The half-life is also doubled. Therefore, for liver diseases, treatment is prescribed extremely carefully.

Indications

Gelmadol is prescribed in the presence of roundworms (nematodes) or damage to the body by nematodes:

• Ascariasis - the causative agent of this disease is human roundworm;
• Enterobiasis - this disease occurs when pinworms enter the body, most often occurs in children of preschool and school age;
• Strongyloidosis - intestinal acne provokes this disease;
• Ankylostomiasis - the causative agent of this disease are hookworms;
• Necatorosis - when ingested, nekatorosis provoke this disease;
• Filariasis - the causative agents of this ailment are various types of filarias;
• Capillariasis - the provocateurs of this disease are parasites called capillaria;
• Toxocariasis - this disease is provoked by toxocars;
• The cutaneous form of the "migratory larva" syndrome - this disease is complicated by the fact that its pathogen is constantly moving in the body, which complicates the treatment process.

Helmadol successfully treats cestodosis, damage to the body with tapeworms:

• Echinococcosis of the peritoneum, lungs and liver (the causative agents of this disease are the larvae of the unicameral echinococcus);
• Neurocyticercosis (a parasitic disease of the nervous system caused by the larva of the pork tapeworm).

The drug also works successfully against Trematodosis, provoked by dysgenetic flukes.

• Opisthorchiasis (the disease is localized in the pancreas and liver and is provoked by the Siberian fluke);
• Fascioliasis (the causative agent of this disease is hepatic and giant flukes).

Assign Gelmadol for protozoal infection or damage by parasitic protists (unicellular parasites). On all of the above parasites, this drug acts equally depressing.

Not all of the above diagnoses appear on the list of indications in the official instructions. Already after compiling the latter, it was revealed that this drug has a wider range of work than it was originally identified.

Contraindications

Lactation

This drug is categorically contraindicated for use in children under 2 years of age. It is also better to refrain from using this drug during pregnancy, as the drug crosses the placenta. During breastfeeding, it is also better to refuse Gelmadol. If you still need to take the drug, you must refuse to breastfeed for the duration of treatment.

If there are components in the drug that are intolerable by the patient's body, the drug should also be abandoned. In the case of diseases of the retina, this drug is also contraindicated. With extreme caution, it is prescribed for liver and kidney diseases.

With all existing diseases, it is worth notifying the doctor in advance so that he has a more complete picture of the state of the body and the possibility of prescribing this drug.

Carefully

In addition to the fact that there are a number of strict contraindications for taking this medication, there are also a number of restrictions that it also makes sense for patients to know about.

For these diseases, the drug is not contraindicated, but its reception requires constant monitoring by the attending physician:

• Depression of brain function;
• Cirrhosis of the liver;
• Liver failure;
• Cysticercosis of the eyes.

Gelmadol - instructions for use

Gelmadol is prescribed for most helminths. The tablets must be taken orally with or immediately after meals. Additional preparation treatment with this drug is not required. There is also no need for diets or bowel cleansing procedures. The dosage of the drug takes place in each case according to an individual scheme and it depends on weight, age, diagnosis and degree of damage to the body by helminths.

At the same time, there are general rules from which it is not recommended to deviate. So the maximum daily dose of the drug should not exceed 800 mg of the active substance for an adult. For children, the maximum dosage should not exceed 400 mg. Otherwise, the likelihood of adverse reactions and overdose increases many times. In the tissues of the liver and kidneys, irreversible processes can occur.

With ascariasis and trichocephalosis, patients with a body weight of 60 kg and more are prescribed 400 mg of the drug once, you can split this portion into two doses. With a patient weighing up to 60 kg, the daily rate is calculated according to the scheme of 15 mg / kg of the patient's body weight. The resulting portion can be taken in one go or divided into two doses.

In the case of enterobiasis, the drug is prescribed according to the following formula: 5 mg / kg of the patient's weight should be taken once. To consolidate the result and in order to prevent relapse, repeat the drug intake after two weeks. The dosage is the same.

Strongyloidosis and ankylostomiasis are prescribed at the rate of 10 mg / kg of the patient's body weight. You need to take it once a day for three days. A week later, taking the drug must be repeated, the treatment regimen is the same.

Trichinosis requires a different scheme. 10 mg of the active ingredient for each kg of the patient's body weight. It should be taken twice a day for a week, with more severe invasions, the treatment period can be extended to 10 days. In the case of myocarditis, pneumonitis, meningoencephalitis, concomitant glucocorticosteroid and symptomatic agents are prescribed.

With Toxocariasis, the drug is taken twice a day after meals. The drug should be drunk for 10 days. After two weeks, a maximum of a month later, the entire course should be repeated again. While taking the drug, it is necessary to control peripheral blood. It should be taken at least once a week. In addition, aminotransferase control will be required.

With hydatid echinococcosis, a thorough biochemical blood test is required before starting treatment. In the case of normal laboratory indications, treatment can be performed. Prescribed at the rate of 10 mg per kg of the patient's body weight. The resulting volume should be divided into 2-3 doses. The drug should be taken for four weeks. Three courses of treatment are required, with a two-week break between each.

During therapy, it is required to donate blood for analysis every week, in case of a decrease in leukocytes and a 5-6-fold increase in the content of aminotransferases, you should immediately stop taking the drug and consult with your doctor. After normalization of the indications, treatment should be continued.

Gelmadol is often prescribed as an adjunctive agent for chemotherapy of alveolar echinococcosis. The reception scheme is identical to the previous one. The duration of the course is assigned based on the patient's condition and drug tolerance.

Cysticercosis is prescribed on the basis of 15 mg / kg of the patient's body weight. The resulting volume is divided by three times and taken throughout the day. The duration of the course is one month. Two days before the start of treatment and the entire first week of taking the drug, glucocorticosteroids should be taken. Before the start of therapy and at its completion, blood monitoring is required for the content of leukocytes and aminotransferases.

It should be remembered that these diagrams are approximate. In no case should you arbitrarily change the dosage and treatment regimen. This can only be done by the attending physician.

Adverse reactions

Albendazole is a fairly toxic substance, so the likelihood of adverse reactions is not excluded. To keep them to a minimum, in no case should you deviate from the prescribed dosages. We must not forget that the consumption of fatty foods increases the likelihood of adverse reactions:

• From the gastrointestinal tract, pain in the stomach is likely, there is a risk of acute disorders in the liver;
• On the part of the hematopoietic organs, there is a high probability of the development of such deviations as inhibition of all hematopoietic processes in the bone marrow, pathologies such as leukopenia, thrombocytopenia and other disorders can develop;
• Headaches, general weakness of the body, confusion, loss of coordination of movements may appear, symptoms of meningitis are likely;
• While taking the drug, existing renal diseases may worsen;
• Itching, spots may appear on the skin;
• If any component is intolerant, there is a risk of developing an allergic reaction, which may manifest itself in the form of Quincke's edema;
• Body temperature may rise, hair begins to fall out.

Overdose

If you strictly adhere to the prescribed regimens, an overdose situation is unlikely. However, in some cases, the risk still remains. It manifests itself in the form of diarrhea, vomiting, dizziness, tachycardia. In some cases, breathing difficulties may occur.

In case of an overdose, it is required to immediately flush the stomach by drinking as much warm water as possible and pressing on the root of the tongue to provoke vomiting. Treatment is symptomatic. The patient needs constant monitoring until his condition stabilizes.

Gelmadol during pregnancy

Due to the fact that albendazole is very toxic, while it has the property of penetrating into all organs, including human fluids, it can provoke pathologies in the formation of the internal organs and the brain of the baby. Taking the drug can cause freezing of fetal development, up to a spontaneous miscarriage. Therefore, taking this drug during pregnancy is categorically contraindicated.

For women of childbearing age, the drug is also not prescribed until it is firmly certain that she is not pregnant. A pregnancy test is sufficient. Contraceptives should be taken during the entire treatment.

In case of breastfeeding, Gelmadol is also contraindicated. If you urgently need to undergo a course with this anthelmintic agent, it makes sense to refuse breastfeeding for the duration of treatment.

special instructions

In the first weeks of treatment, especially if the course is long, constant monitoring of the blood test is required. It is important that the level of leukocytes does not decrease, and the content of aminotransferases does not increase. In case of serious failures in the indications, the drug should be discontinued until the standards are completely stabilized.

Also, in the case of long-term therapy, liver function tests are required in the middle of each cycle. If at least one of the enzymes is more than doubled, the drug should be discontinued until the patient's condition is completely stabilized. It is especially important to carry out all these tests in children.

To have a complete picture of the state of the patient's body, before starting treatment, it is necessary to conduct a biochemical blood test. Gelmadol can be used only if all indicators are normal.

Before starting treatment with Gelmodol, like any other anthelmintic agent, you need to carefully clean the apartment, change bedding, wash all children's toys, and change underwear. Before going to bed and after taking a shower, change your underwear. During treatment and a few days after, bed linen should be thoroughly ironed with a hot iron. Observe personal hygiene, trim nails, wash hands thoroughly with soap, do not comb the anus.

In the case of enterobiasis, it makes sense to drink this drug to all family members living with the patient, even if there are no external signs of invasion. It should be remembered that the disease very often passes in a latent form.

Interaction

The use of drugs intended to correct blood sugar levels, anticoagulants, oral contraceptives and theophylline during Helmadol therapy should be agreed with the attending physician. Since in some cases, these combinations can lead to an increase in the concentration of the active substance of the latter.

The joint administration of Gelmadol with anticonvulsants also requires special control.

The use of grapefruit can also lead to an increase in the development of side reactions, so the latter should also be abandoned during therapy.

Impact on the ability to drive vehicles

In view of the fact that Gelmadol causes rather severe adverse reactions, driving and other mechanisms that require increased concentration of attention and psychomotor reactions should be abandoned.

Gelmadol: analogues

This drug has many analogs, both structural and the effect on the body. The price for a blister of two Helmadol tablets is about 200 rubles. It makes sense to consider analogs if the patient has contraindications to Gelmadol or if there is a persistent intolerance to any component. In no case should you replace the drug spontaneously. Even structural analogs. This can only be done by the attending physician.

1. Nemozole. It is a structural analogue of Gelmadol, since it is also based on albendazole. But unlike its counterpart, it is available not only in tablets, but also in the form of a suspension, which allows it to be given from an early age. The main indications are completely consistent with Gelmadol. Like the latter, it has a number of contraindications and side reactions. Manufactured by an Indian pharmaceutical firm. At a cost a little more democratic than Gelmadol - from 100 rubles per package.

2. Sanoksal. It is also an Indian anthelmintic. Also a structural analogue of Gelmadol. Available in 400 mg chewable tablets. Suitable for use in adults and children from the age of three. The treatment regimen and dosage also depend on age, weight, diagnosis and severity of the disease. Also, like the previous drugs, it has a number of contraindications and adverse reactions. In pharmacies, they ask for this drug from 150 rubles.

   

   Nemozole

   

   Sanoksal

3. Zentel. Also a structural analogue of Gelmadol. Available in both tablets and syrup. In view of the coincidence in the structural component, this drug has the same list of indications for use as the previous analogues. Allowed for use in children from a year. Treatment regimens and dosages directly depend on the patient's weight, diagnosis and age. The price in pharmacies starts at about 190 rubles.

4. Pharmox. It is also a structural analogue of this drug. It is produced in the form of a suspension, so it is ideal for treating children. The range of applications is the same as for the previous drugs. Each disease has its own scheme for use. During treatment, a blood test should be monitored.

   

   Zentel

   

   Pharmox