Table of contents:
Video: Instructions For Use Of Levamisole And Dosage Of Tablets
- 1 Composition and description
- 2 Instructions for use of the drug
- 3 Contraindications
- 4 Side effects
- 5 Analogs
Treatment of many diseases caused by helminths is impossible without the use of special drugs that have a detrimental effect on parasites. The mechanism of action of these drugs may differ. Some of them paralyze the helminth, others disrupt its metabolic processes, and others increase the permeability of cell membranes. One of the drugs with anthelmintic action is Levamisole. It is often prescribed for the treatment of the most common parasitic diseases. Our article contains instructions for the use of Levamisole.
Composition and description
Levamisole is an almost white, rounded tablet. The surface of the tablets is flat, has a notch and beveled edges. Each of them contains 50 mg of the active ingredient, which is levamisole hydrochloride.
As additional ingredients in the preparation used:
- sodium starch;
- magnesium stearate;
- silicon colloidal dioxide;
- regular starch;
- calcium hydrogen phosphate.
The drug belongs to the group of anthelmintic and immunomodulatory agents used to treat nematodes. Levamisole is a derivative of imidazothiazoles.
The drug has a detrimental effect on helminths due to a violation of the energy metabolism of parasites, inhibition of the processes of fumarate recovery, blockade of succinate dehydrogenase. The active substance contributes to the depolarization of cell membranes in the muscles of the parasites. After the helminths are paralyzed, they are excreted from the body in a natural way during the day due to intestinal peristalsis.
The immunomodulatory effect of the drug is due to the following:
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- It enhances the production of antibodies in response to all kinds of antigens.
- Levamisole enhances the responsive production of T-lymphocytes, and also stimulates T-cell polyiferation.
- Thanks to the drug, the function of monocytes, neutrophils and macrophages increases.
After internal use, it is rapidly absorbed from the intestines. The maximum concentration is observed after 2 hours. The drug is transformed in the liver, forming inactive metabolites, excreted by the kidneys. Only 5% of the drug is removed from the body with feces. 70% of the accepted dosage is excreted in the urine for three days.
Instructions for using the drug
The instructions for Levamisole contain detailed information on how to use it and dosages. The tablets must be taken orally after or during a meal. They can be taken with a little water. It is advisable to take the tablets in the evening.
The dose for the treatment of adults and children from 14 years old is 150 mg (three tablets of 50 mg each). You need to take the entire dose once. For the treatment of helminthiasis in children from two to 14 years old, the drug is prescribed in tablet form in a dosage of more than 100 mg for a single dose. More precisely, the dosage can be determined on the basis that 2.5 milligrams of the drug is needed per kg of the baby's weight. Also, when treating children, you can adhere to the following intake regimen:
- kids from two to 3 years old - half a tablet one-time, which is equal to 25 mg;
- children from three to 6 years old - half or a whole tablet one-time (this is equal to 25-50 milligrams of the drug);
- children aged seven to 10 years take from one to one and a half tablets every knock (that is, 50-75 milligrams of Levamisole);
- children's age 11-14 years - the dosage is one and a half or two tablets, which is equal to 75-100 milligrams of the drug.
With caution, this drug is prescribed for pathologies of the liver, kidneys, impaired hematopoiesis and cerebrovascular disorders. During long-term therapy, it is important to control the concentration of blood leukocytes.
The use of a medicinal product is contraindicated in case of hypersensitivity to its ingredients, as well as in such conditions:
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- if there is a history of agranulocytosis;
- during pregnancy (if the doctor weighs the possible risks for the baby and the benefits for the mother, then the drug can be prescribed during this period);
- not prescribed for children under two years old;
- treatment during breastfeeding is contraindicated (while taking the drug and for 24 hours after that, breastfeeding must be stopped).
An overdose of the drug, that is, taking more than 600 mg of the drug, can lead to confusion, lethargy, headache, vomiting, diarrhea, nausea, seizures and dizziness. For medicinal purposes, it is necessary to flush the stomach, in case of a serious condition, symptomatic therapy is carried out.
With the simultaneous use of Levamisole and Phenytoin, the concentration of the latter in the blood plasma may increase. Against the background of treatment with this drug, it is necessary to adjust the dosage of anticoagulants, since Levamisole enhances their effect. Also, with extreme caution, this medication is prescribed in tandem with drugs that affect the process of hematopoiesis.
You may feel a little dizzy after using this drug. This must be taken into account by people who are going to drive a car or work where increased concentration of attention is required.
When taking this anthelmintic agent, the following side reactions may occur:
- Digestive system: anorexia, nausea, sometimes vomiting and diarrhea, rarely pancreatitis and stomatitis.
- Metabolic processes: an increase in cholesterol levels was rarely observed.
- Hematopoietic system: thrombocytopenia and agranulocytosis.
- Sense organs: impairment of smell and change in taste.
- Nervous system: problems with sleep, increased irritability, sometimes depressive conditions, less often a syndrome like encephalopathy.
- Some allergic manifestations are possible in the form of dermatitis and skin rash.
- Musculoskeletal system: atralgia and myalgia.
- Sometimes, against the background of treatment, flu-like symptoms appear in the form of weakness and fever.
Among the analogs for the main active ingredient, the following drugs can be called:
- Decaris is available in the form of tablets, each of which contains 50 or 150 milligrams of the active ingredient;
- Levamisole-Health. It is also a tablet form of the drug. One tablet contains 150 milligrams of the main substance.
If the doctor prescribed you to take Levamisole in the prescription, then without prior consultation with a specialist, you should not replace the drug with analogues. As you can see, some pills contain more active ingredient, so the dosage of the medicine (especially for treating children) may differ from that prescribed by the doctor.