How Long Does Fluconazole Tablets Work After Taking

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How Long Does Fluconazole Tablets Work After Taking
How Long Does Fluconazole Tablets Work After Taking
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Video: How Long Does It Take Fluconazole To Work? | Ask Eric Bakker 2023, February
  • 1 Composition and description
  • 2 Instructions for use of the drug
  • 3 Contraindications and side effects of Fluconazole
  • 4 Fluconazole's analogs

Fluconazole is a common antifungal agent of synthetic origin. It belongs to the pharmaceutical group of triazoles, it is used for the treatment and prevention of thrush, mycoses and some other pathologies. How long does Fluconazole take effect? The drug begins to work 1.5 hours after application, and the therapeutic effect in many patients is observed after a different time, which is due to the individual characteristics of the organism and the specific disease.

Composition and description

antifungal agent
antifungal agent

The drug is produced in capsule and tablet form, in the form of a gel, syrup, solution for intravenous use, suppositories. The main active ingredient is the drug of the same name. The capsules contain potato starch, calcium and magnesium stearate as auxiliary components. The tablets contain lauryl sulfate.

You can buy different dosages of the drug - 0.1 g, 0.05 g and 0.15 g. Capsules are characterized by blue shades, inside there is a powder of a granular structure - white or slightly yellowish - a variant of the norm. The medication is sold in cardboard boxes, which contain a blister.

After taking Fluconazole, a detrimental effect on fungal enzymes is noted. The active substance blocks the transformation of ergosterol in the cells of pathogenic microorganisms. Under the influence of the drug, there is an increase in the permeability of the cell membrane, inhibition of the process of pathogen activity.

After taking capsules / tablets, the fluconazole substance is absorbed in the human gastrointestinal tract. How long does it take to start acting? It is difficult to answer this question accurately, since the effect of any medication depends on the individual physiological characteristics of the organism. Pills help some people quickly, others have to wait a certain time.

According to the instructions, the maximum concentration of fluconazole is detected eight hours after application, but in reality the component starts to work earlier. One tablet acts for three days, so the symptoms should be completely eliminated during this time. In medical practice, special treatment regimens with Fluconazole are used, which take into account this particular time period, that is, repeated use no earlier than 72 hours later.

Instructions for using the drug

oral thrush
oral thrush

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According to the doctors, the drug is quite effective against various strains of pathogenic and opportunistic microbes, therefore it is often used in the treatment of various pathological processes.

The indications include:

  • Infectious diseases that develop due to abnormal activity of fungi;
  • Oral thrush;
  • Atrophic candidiasis of the mouth (this pathology is inherent in patients who have dentures);
  • Non-invasive bronchopulmonary infections;
  • Genital thrush (vaginal candidiasis, relapse of the disease);
  • Prevention of any type of thrush;
  • Onychomycosis;
  • Cryptococcosis;
  • Deep forms of endemic mycoses, etc.

The drug, which acts relatively quickly, must be taken orally or intravenously (only in a medical institution by infusion at a rate of up to 10 ml in 60 seconds).

Instructions for use:

  1. Disseminated candidiasis and candidemia. The first time, 0.4 g is taken, then the dose is reduced to 0.2 g. The generalized form in childhood is treated at the rate of 5-10 mg per kilogram of body weight.
  2. Oropharyngeal thrush. The dosage ranges from 0.05 g to 0.1 g every day for several weeks.
  3. Atrophic thrush of the oral cavity. Take 0.05 g once a day. The therapy must be combined with the use of local agents, which are used to treat the prostheses. The therapeutic course varies from 2 to 4 weeks.
  4. To prevent recurrence of oropharyngeal thrush in immunocompromised patients, take 0.15 mg every seven days. In childhood, the dosage is calculated as follows: 3 mg of the drug per 1 kilogram of weight. For the first time, give a double dose.
  5. Cryptococcal infectious pathologies. It is recommended to take 0.2-0.4 g once a day. For the first time, take 0.4 g, the next days 0.2 g. The treatment course varies from 6 to 8 weeks.
  6. For infectious pathologies of the skin, 0.15 g is taken in 7 days or 0.05 g for a week every day. The duration of therapy is no more than six weeks.
  7. Patients with a history of pityriasis lichen should be taken 0.3 g every seven days, the course is 14 days.
  8. With onychomycosis, 0.15 g is taken every 7 days. The duration of the course is until a new nail plate grows.

With vaginal candidiasis, it is enough to take a pill / capsule in a dosage of 0.5 g once, as a rule, this is enough to get rid of the uncomfortable problem. In the future, the doctor may recommend a remedy as a prophylaxis to prevent a possible exacerbation.

Contraindications and side effects of Fluconazole

side effects of fluconazole
side effects of fluconazole

The drug is prescribed with extreme caution if there is a history of liver disease, superficial fungal infections. Based on the results of laboratory tests, the doctor can adjust the dosage downward.

Fluconazole is not prescribed in the following situations:

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  • Hypersensitivity to the active ingredient or azole substances, which are characterized by similarity to the structure of fluconazole;
  • It is forbidden to combine Fluconazole and Terfenadine if the treatment involves a dosage of the first drug of 0.4 g per day;
  • Children under 4 years old.

Adverse reactions of the body include pain in the epigastric region, upset digestive processes, increased gas formation in the intestines, and allergic reactions. The development of angioedema due to intolerance to the composition of the medication is not excluded.

During pregnancy, capsules and tablets are prescribed extremely rarely, only for strict medical reasons, when women have already diagnosed a severe fungal process in the body. The drug penetrates into breast milk, lactation must be canceled for the period of treatment.

With the development of anxiety symptoms, the question of further treatment is decided on an individual basis by a medical specialist. The specific symptom, its intensity and severity, the patient's condition, and other moments are taken into account. In some cases, treatment continues despite side effects, and sometimes a drug change is required.

Fluconazole's analogs

fluconazole analogues
fluconazole analogues

Drug analogues include drugs - Vfend, Medoflucon, Intracon, Mikosist, Candizol, Vero-Fluconazole, Flucostat, Diflucan, Nystatin, Diflazon, Fluconazole with the Teva prefix, Fluconazole Stada, etc. Fluconazole really helps with various diseases, although as a medicine for quickly relieving the symptoms of thrush. In some clinical pictures, the drug is not suitable, so the doctor chooses a suitable analogue.

Analogues of the antifungal agent Fluconazole (brief description):

  1. Nystatin is an antifungal drug, the active ingredient is the same name. At the pharmacy you can buy ointment, tablets, suppositories. Cannot be used against the background of chronic and acute pancreatitis, with ulcerative pathologies of the gastrointestinal tract, liver dysfunction. The dose is selected individually, depending on the specific disease, the person's age.
  2. Diflucan contains fluconazole, its dosage is 0.05 g, 0.1 g and 0.15 g - tablet form. Differs in a higher price, no differences were found in the therapeutic effect. Has contraindications: bearing a child, breastfeeding, hypersensitivity.
  3. Medoflucon consists of fluconazole and auxiliary components. Has similar indications for use. The difference is that this drug should not be given to children under 18 years of age.

Fluconazole is a fairly popular drug that helps to cure thrush, candidiasis of various localization, and other diseases. You can buy it at a pharmacy, a doctor's prescription is not required, the price for one capsule is about $ 0.8-1.


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