Table of contents:
- Toxoplasmosis: what is it and how is it dangerous?
- Immunoglobulin G or igg
- Analysis for toxoplasmosis
- Interpretation of analysis results
Video: Toxoplasma: IgG Antibodies Detected, What Does This Mean? Decoding Of Analyzes, Reviews Of Doctors
Last updated 10 February 2018 at 12:07
Reading time: 6 minutes
Most of us do not even know which disease we are spreading. After all, in a normal healthy person, the symptoms of the disease do not even appear.
Meanwhile, toxoplasmosis is a serious disease that can lead to fetal death in a woman in labor. Women, children and immunocompromised people are at risk. Toxoplasmosis can be detected when tested for class g antibodies to toxoplasma.
Toxoplasmosis treatment begins with diagnosis. Modern diagnostic methods are based on the fact that at different stages of the process, antibodies to toxoplasmosis are produced in certain quantities. So, if Toxoplasma igg antibodies are found in the blood what does it mean.
- 1 Toxoplasmosis: what is it and how is it dangerous?
- 2 Symptoms and disease progression
- 3 Immunoglobulin G or igg
- 4 Immunoglobulin M or igm
- 5 Analysis for toxoplasmosis
6 Interpretation of analysis results
6.1 Similar articles
Toxoplasmosis: what is it and how is it dangerous?
The insidiousness of the disease lies in the fact that it practically does not manifest itself in healthy people. But, having discovered itself, it affects the most important human organs for health and vital activity. First of all, it is the central nervous system and visual perception, including the eyes.
Symptoms of the disease are fever, tremors, disorientation in space, lack of focus and coordination, blurry vision, and confusion.
In pregnant women, at the very beginning of pregnancy, Toxoplasma gondii begin to activate. By the end of pregnancy, up to 40% of organs and vital systems can be affected in the fetus. In view of the lack of sufficiently effective means of influencing the disease as a result of the specifics of the state of the female body during pregnancy, such a lesion is guaranteed to lead to serious consequences and can lead to death.
Therefore, tests for toxoplasmosis are the main means of prevention during pregnancy. The World Health Organization includes these tests in the group necessary in the last stages of pregnancy.
Experts insist that studies for toxoplasmosis should be carried out in the early stages of pregnancy, and the effectiveness of these measures can be achieved only with planning and timely testing before conception. Only then can primary infection be prevented.
Since there are no equally effective treatments during pregnancy, the main burden of treatment falls on the antibodies produced. Antibodies can only be produced in the body of a healthy person, therefore, for HIV-infected people, this method of diagnosis and treatment does not always give positive results.
Specific enzymes that fight active toxoplasma are called immunoglobulins in the human body. They begin to be produced already at an early stage of the disease. There are several types of these substances, secreted by the body at different stages of the development of the disease. This is actually the basis for the diagnosis of the stages of development of toxoplasmosis in the human body.
In the process of fighting the parasite, toxoplasmosis produced antibodies enter into communication with the microbe, penetrating into the main systems of its vital activity and life support, with the formation of stable bonds. Subsequently, the destruction of the structure of the simplest cells of the microbe due to the formation of new bonds leads to the destruction of tissues and cells of the parasite, and then to the death of the carrier of the infection.
The antibodies produced are built into the immune system and are stored in the human body for life. Therefore, a relapse of the disease and subsequent infection are no longer possible. In such a situation, the risk group includes a fetus during pregnancy with an undeveloped immune system and people infected with HIV.
Immunoglobulin G or igg
In order for the source of infection, the Toxoplasma gondia parasite, to be destroyed, it must be identified. It is for these purposes that igm immunoglobulin is intended. It serves as a kind of marker for the source of infection.
As soon as the infection in the body has begun, the human immune system begins to produce the corresponding at - markers. They search for primary foci of infection in the body and try to eliminate them. This is the so-called ambulance of our body.
With the usual course of toxoplasmosis, amm with the igm marker begin to be produced on the first day of infection and can disappear, having identified all foci of infection. In this case, the maximum concentration of igm is reached on the twenty-first day.
The maximum concentration of both immunoglobulins in the blood is not a very pleasant thing. She says that after a month of infection, infection is still going on, new foci and affected organs appear, which need to be identified and diagnosed. What is immunoglobulinigm doing.
Analysis for toxoplasmosis
Treatment of a disease begins with its diagnosis. When conducting a study for toxoplasmosis, IFA is almost always used - an immunoassay method of research. It helps not only to establish the infection with a certain accuracy, but also to correctly identify the stage of the process.
Ifa is based on an assessment of the presence and concentration of antibodies of the igg and igm types present during the course of the disease or indicating the presence of a previous infection with the parasite.
The analysis and technique operate with such an indicator as the blood norm. This is the ratio of the presence of these bodies in the blood in quantities indicating that at the moment the patient is not a carrier of an active infection.
Interpretation of analysis results
To decipher the analysis, the IFA technique is used. The analysis is based on the quantitative presence of specific antibodies igg and igm in the body. The amount of antibodies present is measured in units per milliliter. Testing a positive assessment of the indicator at values of three or more units per milliliter.
If doubtful indicators are identified, additional testing and evaluation of the results are carried out 14 days after the first samples. In addition, urine and blood tests are carried out.
Thus, there are four options for sample results:
- igm- igg-;
- igm- igg +;
- igm + igg-;
- igm + igg +;
Toxoplasma igg gave a positive result, which means that the person was infected or the disease is currently active.
- The first results indicate that the person has never had toxoplamosis and has no immunity to this disease.
- The second option is the presence of immunity for the simplest.
- The third test indicates the presence of an initial stage of infection. Recent results may indicate a relapse of the disease in an acute form.
The results of the study are indicated on the study card or analysis form. The norm in the blood means that the body is healthy and repeated tests and treatment are not required.