Trichopolum Analogs - Bacimex, Meter, Eflorak, Flagil, Meter

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Trichopolum Analogs - Bacimex, Meter, Eflorak, Flagil, Meter
Trichopolum Analogs - Bacimex, Meter, Eflorak, Flagil, Meter

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Analogs of Trichopolum are a variety of medicines based on metronidazole, for example: bacimex, methitis, eflorac, flagil, methit, metron. Trichopolum itself is a medicine that is used to treat severe infectious diseases. The drug is made on a synthetic basis and has antimicrobial and antiprotozoal effect.

The content of the article:

  • 1 Trichopolus - what does it heal
  • 2 Pharmacological action
  • 3 Effect on the body and indications for use
  • 4 Side effects
  • 5 Treatment
  • 6 Analogs of Trichopol
  • 7 Analogs of Trichopolum - Metrovit: instructions for use

    • 7.1 Pharmacokinetics
    • 7.2 Indications
    • 7.3 Dosage
    • 7.4 Drug interactions
    • 7.5 Special instructions

Trichopolus - what does it heal

Russian analogue of Trichopol
Russian analogue of Trichopol

Trichopolum (metronidazole) is an antiprotozoal and antimicrobial drug that is used to eliminate certain types of bacterial infections. Trichopolum is taken orally or applied to the skin, depending on the type of infection. In most cases, taking Trichopolum is not accompanied by side effects, but, nevertheless, this possibility should not be ruled out.

pharmachologic effect

Antiprotozoal drug with antibacterial activity for local use in gynecology. Refers to nitro-5-imidazoles. The mechanism of action of metronidazole is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.

Metronidazole is an effective broad-spectrum antimicrobial and antiprotozoal agent.

Shows high activity against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia spp., As well as against obligate anaerobes - Bacteroides spp. (Bacteroides fragilis, Bacteroides ovatus, Bacteroides distasonis, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some gram-positive microorganisms (Clostridium spp., Peptostreptococcus spp., Peptococcuc spp., Eubacterium spp., Mobiluncus spp.).

Action on the body and indications for use

Russian analogue of Trichopol
Russian analogue of Trichopol

The mechanism of action of Trichopolis is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.

Trichopolum is used to eliminate bacterial infections of the respiratory tract, skin, genitals, joints and the central nervous system.

Side effects

Serious side effects are observed in patients with impaired liver, kidney, bone marrow, nervous system function, as well as in elderly patients. Violation of gait, dizziness and any other deterioration of the neurological status of patients requires discontinuation of treatment with trichopolum. With prolonged therapy (more than 10 days), the peripheral blood picture and liver function should be monitored.

Other side effects include nausea, vomiting, itching and burning of the genitals, coughing, sores in the mouth, swelling of the tongue, bad taste in the mouth, headache, and dizziness.

The possibility of developing dizziness should be taken into account when prescribing the drug to patients whose activities are related to the control of mechanisms, especially to vehicle drivers. During the period of taking Trichopolum, as well as within 72 hours after the last dose of the drug, alcohol should not be consumed.

Trichopolum (flagil) is a broad-spectrum antimicrobial and antiparasitic agent that is used to treat trichomoniasis, giardiasis and peritonitis. It is an antibiotic that inhibits the growth of anaerobic (developing in the absence of oxygen) and protozoal organisms. Like other antibiotics, trichopolum destroys not only harmful, but also beneficial bacteria. In addition, trichopolum creates an alkaline environment in which fungal infections develop faster.

Symptoms of a fungal infection (candidiasis) are thick, cheesy vaginal discharge that is often (but not always) itchy. But for many women, the infection is asymptomatic. If you suspect you have candidiasis, the only way to confirm or dispel your concerns is to visit a gynecologist and get tested. If the diagnosis is confirmed, you can start treatment.

Treatment

The course of treatment with trichopolum should be completed even if there is an improvement and the symptoms of the disease have disappeared. The traditional medicine for candidiasis is antifungal drugs that are taken by mouth or inserted into the vagina.

Over the counter medications for candidiasis:

  • clotrimazole (guinea-lotrimin, mycelex);
  • butoconazole (ginesol or femstat);
  • miconazole nitrate (monistat);
  • thioconazole (vagistat);
  • Clotrimazole and miconazole are sold in tablets, suppositories (suppositories), or vaginal tablets.

Fluconazole is only available with a doctor's prescription as a tablet or intravenous solution.

Trichopolum analogs

Trichopolum analogues are a variety of medicines based on metronidazole, for example, bacimex, methitis, eflorac, flagil, methit, metron. By the way, meter is a Russian analogue of Trichopolum, which is produced in the form of suppositories. It is used to treat bacterial vaginosis and vaginitis, as well as urethritis and several other conditions. In its properties and side effects, it is very similar to Trichopolum vaginal tablets.

If the patient cannot take metronidazole for any reason, he may be prescribed one or another replacement for trichopolum. It is most often replaced with clindamycin or tinidazole.

Trichopolum analogs. Tinidazole is used to treat trichomoniasis, giardiasis (an infection of the intestines that can cause diarrhea, increased gas and stomach cramps), amebiasis, and several other infections. It is usually taken with a meal, in one dose, or once a day for three to five days. It is important to take tinidazole at approximately the same time to maintain a certain concentration of the drug in the body.

Tinidazole is contraindicated in people who are allergic to both this drug and metronidazole; therefore, those who cannot take Trichopolum due to allergies are likely to be prescribed clindamycin. Before you start taking tinidazole, be sure to tell your doctor if you are taking medications such as warfarin, fluconazole, itraconazole, ketoconazole, carbamazepine, clarithromycin, cyclosporin, danazol, diltiazem, erythromycin, fluvoxamine, lithium, combined oral contraceptives, phuvoxamine, rifampicin.

Russian analogue of Trichopol
Russian analogue of Trichopol

Tinidazole can cause the following side effects: a strong metallic taste in the mouth, upset stomach, poor appetite, vomiting, constipation, stomach pain, headache, fatigue, weakness, dizziness.

Trichopolum analogues - Clindamycin is used to treat a variety of bacterial infections that affect the lungs, skin, female reproductive organs, other internal organs, and blood. The duration of the course of treatment depends on the infection for which the drug is used. As a rule, improvement occurs within a few days after the start of clindamycin; if this does not happen, or if the symptoms of the illness worsen, see your doctor.

Before starting treatment, tell your doctor if you are allergic to clindamycin, have a history of asthma, eczema, liver or kidney disease, or if you are pregnant or breastfeeding. Clindamycin can cause side effects such as nausea, vomiting, joint pain, pain when swallowing, heartburn, white patches in the mouth, white, thick vaginal discharge, burning and itching in the vagina.

Trichopolum analogs - Metrovit: instructions for use

Antiprotozoal agent. It is believed that the mechanism of action is associated with a violation of the structure of the DNA of sensitive microorganisms. It is active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia lamblia, Entamoeba histolytica, as well as obligate anaerobic bacteria (including Bacteroides spp., Fusobacterium spp.).

Aerobic microorganisms are resistant to metronidazole.

In combination with amoxicillin, it is active against Helicobacter pylori. It is believed that amoxicillin inhibits the development of Helicobacter pylori resistance to metronidazole.

Pharmacokinetics

Russian analogue of Trichopol
Russian analogue of Trichopol

Well absorbed after oral administration. Bioavailability is 80%. Distributed in tissues and body fluids. Penetrates through the placental barrier and the BBB. Plasma protein binding - 20%. It is metabolized in the liver by oxidation and binding with glucuronic acid. T1 / 2 is 8 hours. It is excreted in urine (60-80%) and feces (6-15%).

Indications

Trichomonas vaginitis and urethritis in women, Trichomonas urethritis in men, giardiasis, amoebic dysentery, anaerobic infections caused by microorganisms sensitive to metronidazole, combination therapy of severe mixed aerobic-anaerobic infections. Prevention of anaerobic infection during surgery (especially on the abdominal organs, urinary tract). Chronic alcoholism.

In combination with amoxicillin: chronic gastritis in the exacerbation phase, gastric ulcer and duodenal ulcer in the exacerbation phase, associated with Helicobacter pylori.

For external and local use: treatment of rosacea and acne vulgaris, bacterial vaginosis, treatment of non-healing wounds, trophic ulcers.

Dosage

Inside for adults and children over 12 years old - 7.5 mg / kg every 6 hours or 250-750 mg 3-4 times / day. Children under 12 years old - 5-16.7 mg / kg 3 times / day.

Trichopolum analogs. When administered intravenously to adults and children over 12 years old, the initial dose is 15 mg / kg, then 7.5 mg / kg every 6 hours or, depending on the etiology of the disease, 500-750 mg every 8 hours. Duration of treatment courses and their frequency carrying out is determined individually.

Intravaginally - 500 mg once a night.

In combination with amoxicillin (2.25 g / day), the daily dose of metronidazole is 1.5 g; frequency of admission - 3 times / day. For patients with severe renal impairment (CC less than 30 ml / min) and / or liver, the daily dose of metronidazole is 1 g (amoxicillin - 1.5 g / day); frequency of admission - 2 times / day.

Topically and topically applied 2 times / day, the dose is set individually.

The maximum daily dose for adults for oral and intravenous administration is 4 g.

Drug interactions

Russian analogue of Trichopol
Russian analogue of Trichopol

With simultaneous use with antacids containing aluminum hydroxide, with cholestyramine, the absorption of metronidazole from the gastrointestinal tract is slightly reduced. With the simultaneous use of metronidazole potentiates the action of indirect anticoagulants. With simultaneous use with disulfiram, acute psychoses and impaired consciousness may develop.

It is impossible to exclude an increase in the concentration of carbamazepine in the blood plasma and an increase in the risk of developing toxic effects when used simultaneously with metronidazole.

With simultaneous use with lansoprazole, glossitis, stomatitis and / or the appearance of a dark color of the tongue are possible; with lithium carbonate - it is possible to increase the concentration of lithium in the blood plasma and develop symptoms of intoxication; with prednisone - the excretion of metronidazole from the body increases due to the acceleration of its metabolism in the liver under the influence of prednisone. A decrease in the effectiveness of metronidazole is possible.

With simultaneous use with rifampicin, the clearance of metronidazole from the body increases; with phenytoin - a slight increase in the concentration of phenytoin in the blood plasma is possible, a case of the development of a toxic effect is described.

With simultaneous use with phenobarbital, the excretion of metronidazole from the body is significantly increased, apparently due to the acceleration of its metabolism in the liver under the influence of phenobarbital. A decrease in the effectiveness of metronidazole is possible.

When used simultaneously with fluorouracil, the toxic effect is enhanced, but not the effectiveness of fluorouracil.

A case of the development of acute dystonia after taking a single dose of chloroquine in a patient receiving metronidazole is described.

With simultaneous use with cimetidine, it is possible to inhibit the metabolism of metronidazole in the liver, which can lead to a slowdown in its excretion and an increase in plasma concentration.

With the simultaneous use of ethanol in patients receiving metronidazole, disulfiram-like reactions may develop.

special instructions

Use metronidazole with caution in liver diseases.

In combination with amoxicillin, it is not recommended for use in patients under 18 years of age. In the course of treatment, systematic monitoring of the peripheral blood picture is necessary.

Trichopolum analogs. During the treatment of Trichomonas vaginitis in women and Trichomonas urethritis in men, it is recommended to abstain from sexual activity; simultaneous treatment of both partners is mandatory.

During the use of metronidazole, a darker coloration of urine is observed.

During treatment with metronidazole, alcohol should be avoided. due to the violation of alcohol oxidation, the accumulation of acetaldehyde can occur. As a result, reactions may develop that are similar to those characteristic of disulfiram (spastic abdominal pain, nausea, vomiting, headache, sudden flushing of the face).

Find out more:

  • Trichopol - instructions for the use of tablets in gynecology
  • Trichopol - instructions for use, indications
  • Tinidazole: indications and instructions for use in tablets

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