Table of contents:
- Trichopolum dosage forms
- Trichopolum mechanism of action
- Trichopol - instructions for use
- Trichopol - instructions for use in gynecology
- Gynecological diseases that Trichopolum treats
- The use of trichopolum during pregnancy
- Trichopol - instructions for use in gynecology
- Side effects when using the drug Trichopol (Metronidazole)
- Special instructions for the use of Trichopolum
- Trichopolum drug analogues
- Price, storage conditions of the drug Trichopol
Video: Trichopol - Instructions For The Use Of Tablets In Gynecology
Trichopolum - the instruction defines a wide spectrum of action and is often prescribed for the treatment of diseases of the genitourinary system. The use of Trichopolum in gynecology provides for the treatment of trichomoniasis, colpitis, gonorrhea, parametritis, vulvitis, etc.
The content of the article:
- 1 Dosage forms of Trichopolum
- 2 The mechanism of action of Trichopolum
3 Trichopol - instructions for use
- 3.1 Symptomatic trichomoniasis
- 3.2 Asymptomatic trichomoniasis
- 3.3 Amoebiasis
- 3.4 Anaerobic bacterial infections
- 4 Trichopolum - instructions for use in gynecology
5 Gynecological diseases that Trichopolum treats
- 5.1 Vulvitis
- 5.2 Bartholinitis
- 5.3 Colpitis
- 5.4 Endocervicitis
- 5.5 Endometritis
- 5.6 Salpingo-oophoritis
- 5.7 Trichomoniasis
- 5.8 Pelvioperitonitis
- 5.9 Parameter
- 5.10 Gonorrhea
- 5.11 Candidiasis
- 5.12 Chlamydia
- 6 The use of trichopolum during pregnancy
- 7 Trichopolum - instructions for use in gynecology
- 8 Side effects when using the drug Trichopol (Metronidazole)
- 9 Special instructions for the use of Trichopolum
- 10 Analogs of the drug Trichopolum
- 11 Price, storage conditions of the drug Trichopol
Trichopolum dosage forms
The tablets are oblong, biconvex, white or light yellow.
Trichopolum is available in the following dosage forms:
- oral tablets containing 250 mg metronidazole
- vaginal tablets containing 500 mg of metronidazole
- solution for infusion in 20 ml ampoules containing 100 mg of metronidazole in an ampoule (or 5 mg of metronidazole in one ml of solution)
- solution for infusion in 100 ml polyethylene bottles containing 500 mg of metronidazole in an ampoule (or 5 mg in 1 ml of solution)
Trichopolum mechanism of action
The drug is used in the form of vaginal suppositories, tablets and solutions for intravenous injections. Tablets contain 250 mg of Metronidazole. Assign for trichomoniasis in adults 1 tablet 2 times a day after meals. The course is 10 days.
For the best effect and exclusion of further infection, treatment should be carried out simultaneously by both sexual partners. With amoebiasis, tablets are prescribed after meals 3 times a day, the duration of admission is up to 15 days.
Trichopolum - instructions for use for giardiasis: the daily dose for children under 5 years old is 1 tablet, from 6 to 10 years old - 375 mg / day, for adults - 2 tablets. The course of treatment is about 7-10 days. If necessary, the doctor can prescribe a second treatment in a month. For infections caused by anaerobic bacteria, Trichopol - instruction. Women are additionally recommended treatment with vaginal suppositories. Each candle contains 500 mg of active ingredient. It is introduced once a day at night. The recommended course is also 10 days. Before the introduction, the candle (it has the form of a large white-yellowish tablet with rounded edges) must be moistened in boiled water. During menstruation, treatment is not stopped.
Metronidazole should be used in combination with other antibacterial drugs. Adults are prescribed 1 - 2 tablets 3 times a day during or after meals. Children under 12 years old are prescribed a fractional dose at the rate of 7.5 mg / kg of body weight, 3 times a day during or after meals.
For the prevention of infections, 4 tablets are prescribed per day. Then, on the recommendation of a doctor, the dose is reduced to 3 tablets per day. The drug is also taken during or after meals. Children - half a tablet 3 times a day. For newborns and toddlers under 5 years of age, the dose of the drug is prescribed individually, and the treatment is carried out under the strict supervision of a doctor.
Trichopol - instructions for use
Trichopolum is prescribed as a treatment for symptomatic trichomoniasis, if the presence of Trichomonas in the body is confirmed by appropriate laboratory tests.
Trichopolum can be prescribed for women who have disorders such as endocervicitis, cervicitis, or cervical erosion. Since there is evidence that the presence of Trichomonas in the body can negatively affect the accuracy of the cytological smear tests, after the destruction of the parasite, the tests are repeated.
Simultaneous treatment of partners: Since Trichomonas vaginalis is sexually transmitted, even if one or both partners are asymptomatic, they must be treated simultaneously.
If the partner of an infected person tests negative for trichomoniasis, he or she must decide on treatment.
Trichopol - instruction. When making such a decision, it must be borne in mind that in the absence of symptoms in a male partner, it can be very difficult to identify Trichomonas, and even negative test results do not always guarantee the absence of infection.
At the same time, if the man has not received treatment, there is a high probability of re-infection of the woman. Therefore, treatment of both partners is usually recommended, even if only one of them has signs of trichomoniasis.
Trichopolum is indicated in the treatment of acute intestinal amebiasis (amoebic dysentery) and amoebic liver abscess. In patients with amoebic liver abscess, taking Trichopolum does not eliminate the need to drain pus from the liver.
Anaerobic bacterial infections
Trichopolum is used to treat serious infections caused by anaerobic bacteria. It is prescribed to prevent such infections after surgery. In the case of mixed aerobic and anaerobic infection, in addition to trichopolum, other antimicrobial agents are prescribed.
To reduce the risk of developing drug resistance in bacteria, trichopolum should be prescribed only in cases where the presence of infection is confirmed by tests, or there are good reasons for suspecting that the patient is infected, or that he will be especially vulnerable to infectious agents (as after surgery).
More specifically, Trichopolum is used to treat the following infections:
- intra-abdominal infections, including peritonitis, intra-abdominal abscess, liver abscess, caused by bacteria from the genera Bacteroides, Clostridium, Eubacterium, Peptococcus niger, and Peptostreptococcus;
- skin infections caused by bacteria from the genera Bacteroides, Clostridium, Peptococcus niger, Peptostreptococcus, and Fusobacterium;
- gynecological infections, including endometritis, endometriosis, tubo-ovarian abscess;
- bacterial sepsis caused by bacteria from the genus Bacteroides and Clostridium;
- bone and joint infections (Trichopolum is prescribed as part of additional therapy) caused by the bacteria Bacteroides;
- central nervous system infections caused by Bacteroides bacteria;
- lower respiratory tract infections, including pneumonia, empyema and lung abscess, caused by bacteria of the genus Bacteroides;
- endocarditis caused by the bacteria Bacteroides.
Trichopol - instructions for use in gynecology
Trichopolum is vaginally used in the form of intravaginal tablets for local treatment of women and girls. Oral tablets are also used to eliminate gynecological infections.
Indications for use are diseases caused by anaerobes, which include: nonspecific vaginitis; bacterial vaginosis; Trichomonas vaginitis; trichomoniasis.
Gynecological diseases that Trichopolum treats
Now we will briefly tell you what gynecological diseases are in women.
Inflammation of the external female genital organs. Primary vulvitis occurs as a result of trauma with subsequent infection (itching, scratching, abrasions, etc.)
Secondary vulvitis in women occurs when there is an inflammatory process in the internal genital organs.
Inflammation of the large gland of the vestibule of the vagina.
Colpitis is an inflammation of the vaginal mucosa.
The inflammatory reaction can be both focal and diffuse, spreading to the vaginal part of the cervix and vulva.
Inflammation of the mucous membrane of the cervical canal. The occurrence of endocervicitis is facilitated by ruptures of the cervix (during childbirth, abortion), diseases of other parts of the reproductive system.
Inflammation of the lining of the uterus. Acute endometritis - more often occurs after abortion, childbirth or diagnostic curettage of the uterus.
Trichopol - instruction. Chronic endometritis, as a rule, occurs as a result of acute postpartum or post-abortion endometritis, untreated until the end, often repeated intrauterine interventions in connection with uterine bleeding contribute to its development.
Inflammation of the uterine appendages is one of the most common diseases of the reproductive system. It usually arises by an ascending route when the infection spreads from the vagina, uterine cavity, most often in connection with complicated childbirth and abortion, as well as descending - from adjacent organs (appendix, rectum and sigmoid colon) or by hematogenous route.
The course of salpingo-oophoritis can be acute, subacute and chronic. The severity of the inflammatory process of the fallopian tubes and ovaries depends on the virulence of the pathogen, on the extent of the spread of the process along the peritoneum and on the reactivity of the body. As complications of inflammatory processes, saccular formations of the uterine appendages - pyosalpinx, ovarian abscess, lipo-ovarian formations can be considered.
An infectious disease caused by Trichomonas vaginalis. Trichomoniasis is sexually transmitted. Trichomoniasis is characterized by multifocal lesions.
Trichopol - instruction. Most often Trichomonas affects the vagina, less often - the urethra, bladder, excretory ducts of the large glands of the vestibule of the vagina, the very vestibule, the mucous membrane of the cervical canal, appendages.
Pelvioperitonitis is a swelling of the pelvic peritoneum. A special form of pelvioperionitis is the abscess of the rectal-uterine pocket of the peritoneum, which can occur with rupture of the pyosalpinx, pyovar, perforation of the uterus during an out-of-hospital abortion, hematoma suppuration in case of disturbed tubal pregnancy.
Parametritis - inflammation of the peri-uterine tissue. Predisposing factors for the onset of parametritis (outside of pregnancy) can be dilatation of the cervical canal, diagnostic curettage, surgery on the cervix, insertion of an IUD with trauma to the walls of the uterus, and removal of an intraligamentary tumor. And also occurs after pathological childbirth.
Gonorrhea is a sexually transmitted disease caused by gonococci. The main route of infection with gonorrhea is sexual. Gonorrhea is characterized by a predominant lesion of the mucous membranes of the genitourinary organs. There are two ways of spreading gonorrhea: ascending - the urethra, cervix, endometrium, tubes, peritoneum and hematogenous - the penetration of gonococci into the bloodstream.
Topographically, there are ascending gonorrhea, gonorrhea of the urinary system, rectal gonorrhea, metastatic gonorrhea. According to the clinical course, fresh and chronic gonorrhea is distinguished. Fresh gonorrhea, in turn, is divided into acute, subacute and torpid.
There are the following inflammatory processes of gonorrheal etiology: gonorrheal urethritis, gonorrheal bartholinitis, endocervicitis, gonorrheal proctitis, gonorrheal endometritis, salpingo-oophoritis, oophoritis, gonorrheal pelvioperitonitis, ascending gonorrhea. Gonorrheal infection occurs in 5-25% of patients, ranking second after trichomoniasis.
Candidiasis is a disease caused by yeast-like fungi. Fungi of the genus candida are part of the normal microflora of a healthy person, but under certain conditions they can cause the disease - candidiasis. Distinguish between candidiasis of the vulva, vagina, uterus and uterine appendages.
Trichopol - instruction. Viral diseases of the genital organs are caused by two groups of viruses. The defeat of the uterus, fallopian tubes and bladder is caused by the herpes virus, damage to the cervix and urethra is a urogenital virus. The causative agent of genital warts is a filterable virus.
Chlamydia is a disease caused by chlamydia. Chlamydial etiology can be colpitis, cervicitis, erosion, urethritis, salpingitis, proctitis, etc.
Tuberculosis of the female genital organs: tuberculosis is a common infectious disease, one of the local manifestations of which is the defeat of the genital organs.
Genital tuberculosis is a secondary process, the primary source of which is the tuberculous focus. According to the localization of the process, tuberculosis of the appendages, uterus, cervix, vagina, vulva is distinguished. Downstream can be acute, subacute and chronic. Genital tuberculosis can occur in combination with pulmonary tuberculosis (up to 90%).
The use of trichopolum during pregnancy
Trichopolum is contraindicated in the first trimester of pregnancy, in the II-III trimesters - take with caution only if the benefits to the pregnant woman outweigh the risk to the unborn child, given that metronidazole crosses the placenta. FDA category of action on the fetus - B.
Trichopolum (metronidazole) is excreted in breast milk, creating concentrations similar to those in blood plasma. May impart a bitter taste to breast milk. To exclude the effect of Trichopolum on the child, breastfeeding while taking Trichopolum and 2 more days after the end is not recommended.
Trichopol - instructions for use in gynecology
Intravaginal tablets or suppositories Trichopolum are used for insertion into the vagina. The tablets must be removed from the packaging, slightly moistened with chilled clean water and inserted as deep as possible.
Oral tablets are taken during or after meals, they are not chewed, they are washed down with water. With trichomonas vaginitis, one piece per day is prescribed for a course of 7-10 days when combined with taking pills. With vaginitis, bacterial vaginosis, 1 suppository is prescribed for a weekly course. Treatment should not be repeated more than 2-3 times a year.
According to the instructions, Trichopolum in the form of a solution is used for intravenous infusion. A cloudy liquid with a precipitate that remains after administration for reuse is not used. If the liver malfunctions, the dosage is adjusted.
Side effects when using the drug Trichopol (Metronidazole)
Trichopol - instructions for use when using the drug Trichopolum, side effects of the body can be observed.
From the digestive system: pain in the stomach, nausea, vomiting, diarrhea, constipation, intestinal colic, decreased or lack of appetite, taste disturbance, unpleasant metallic taste in the mouth, dry mouth, glossitis, stomatitis; very rarely - deviation from the norm of liver function tests (ALT, AST, Bilirubin), jaundice, pancreatitis.
From the nervous system: with prolonged use - headache, dizziness, impaired coordination of movements, ataxia, peripheral neuropathy, hyperexcitability, irritability, depression, sleep disturbance, drowsiness, weakness; in some cases - confusion, hallucinations, convulsions; very rarely - encephalopathy.
From the urinary system: cystitis, polyuria, urinary incontinence, urine staining red-brown.
From the reproductive system: excessive development of the fungal flora of the vagina (including vaginal candidiasis), pain in the vagina.
Allergic reactions: skin rash, itching, hives, nasal congestion, fever.
From the musculoskeletal system: myalgia, arthralgia.
From the hematopoietic system: leukopenia; rarely - agranulocytosis, neutropenia, thrombocytopenia.
Others: extremely rare - toxic effects on the hearing aid; pustular eruptions.
Special instructions for the use of Trichopolum
Trichopolum should be prescribed with caution in patients with severe hepatic impairment. as a result of a slowdown in metabolism, the concentration of metronidazole and its metabolites in plasma increases.
Caution is required when prescribing Trichopolum to patients with inhibition of bone marrow hematopoiesis and central nervous system functions, as well as to elderly patients. The appearance of ataxia, dizziness and any other deterioration in the neurological status of patients requires discontinuation of treatment.
With long-term therapy with metronidazole (more than 10 days), the peripheral blood picture and liver function should be monitored.
With leukopenia, the possibility of continuing treatment depends on the risk of developing an infectious process. The use of metronidazole in patients with porphyria should be avoided.
When treating Trichomonas vaginitis in women and Trichomonas urethritis in men, it is necessary to refrain from sexual activity. Simultaneous treatment of sexual partners is mandatory. After trichomoniasis therapy, control tests should be performed during three successive cycles before and after menstruation.
After treatment of giardiasis, if symptoms persist, after 3-4 weeks, it is necessary to carry out 3 feces analyzes at intervals of several days (in some successfully treated patients, lactose intolerance caused by invasion may persist for several weeks or months, resembling the symptoms of giardiasis).
Patients should refrain from drinking alcohol during metronidazole therapy, as well as for at least 48 hours after the end of treatment, due to the possibility of disulfiram-like reactions: abdominal pain of a spastic nature, nausea, vomiting, headache, sudden rush of blood to face.
During treatment with metronidazole, urine may turn dark or reddish-brown in color due to the presence of water-soluble dyes. Trichopolum can cause immobilization of treponemas, which leads to a false positive Nelson's test.
In combination with amoxicillin, it is not recommended to use Trichopolum in children and adolescents under 18 years of age.
When taking the drug, you should avoid potentially hazardous activities that require increased concentration of attention, speed of psychomotor reactions, especially driving vehicles and maintenance of mechanisms.
Trichopolum drug analogues
Trichopolum can be replaced by funds based on the same active ingredient or having similar antiprotozoal and antibacterial actions.
- Metrogyl: solution, tablets and gel based on metronidazole, used for infections, sepsis;
- Metronidazole: a tablet analogue of Trichopolum, used to treat infectious diseases;
- Flagil: tablets and suppositories containing metronidazole are used for abscesses, vaginitis;
- Efloran: a substitute for Trichopolum for the treatment of protozoal infections;
- Gairo: ornidazole-based antiprotozoal drug in tablet format, used in the treatment of trichomoniasis, giardiasis;
- Tiberal: tablets based on ornidazole, have an antiprotozoal effect.
Price, storage conditions of the drug Trichopol
You can buy drugs in the Trichopol line only with a doctor's prescription. They are stored at temperatures up to 25 degrees.
According to the instructions, the shelf life of tablets for oral administration and solution is five years, for vaginal suppositories - three years.
Medicines can be bought in the online store or ordered inexpensively through the pharmacy catalog. Approximate prices in Moscow will be: Tablets 250 mg 20 pcs. - 91 100; vaginal suppositories 500 mg 10 pcs. 294 310; solution bottle 100 ml 0.5% 122 135.
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