Tinidazole: Indications And Instructions For Use In Tablets

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Tinidazole: Indications And Instructions For Use In Tablets
Tinidazole: Indications And Instructions For Use In Tablets

Video: Tinidazole: Indications And Instructions For Use In Tablets

Video: Tinidazole: Indications And Instructions For Use In Tablets
Video: Metronidazole Antibiotics - Mechanism of Action, Indications, and Side Effects 2024, March
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Tinidazole is an antimicrobial drug used to treat various infections, such as vaginitis, trichomoniasis, giardiasis, sepsis, amoebiasis, etc. Tinidazole should be taken as directed by a doctor, following the instructions, the recommended dosage and the procedure for taking.

The content of the article:

  • 1 Release form, composition and packaging of the drug tinidazole
  • 2 Pharmacological action of the drug tinidazole
  • 3 Pharmacokinetics of the drug tinidazole
  • 4 Indications for the use of the drug tinidazole
  • 5 Contraindications to the use of tinidazole
  • 6 Application of tinidazole during pregnancy and lactation
  • 7 Instructions for the use of tinidazole in men
  • 8 Dosage and administration of tinidazole
  • 9 Side effects of tinidazole drug
  • 10 Interaction with other medicinal products
  • 11 Special instructions when using the drug tinidazole
  • 12 Analogs of the drug tinidazole
  • 13 Price, conditions and shelf life of the drug tinidazole

Release form, composition and packaging of the drug tinidazole

The drug is available in the form of coated tablets. The active ingredient of the drug is tinidazole. One tablet contains 500 mg of tinidazole.

Instructions for the drug Tinidazole
Instructions for the drug Tinidazole

Other components of the drug are microcrystalline cellulose, alginic acid, corn starch, sodium lauryl sulfate, magnesium stearate (which make up the tablet core); hypromellose, talc, titanium dioxide (E171), macrogol 6000, propylene glycol (which make up the tablet shell).

Release form of the drug tinidazole:

  • 4 things. - contour cell packaging (1) - cardboard packs.
  • 10 pieces. - contour cell packaging (1) - cardboard packs.
  • 10 pcs. - contour cell packages (2) - cardboard packs.
  • 10 pieces. - contour cell packages (3) - cardboard packs.
  • 10 pieces. - contour cell packages (4) - cardboard packs.
  • 10 pieces. - contour cell packaging (5) - cardboard packs.
  • 4 things. - polymeric containers (1) - cardboard packs.
  • 10 pieces. - polymeric containers (1) - cardboard packs.
  • 16 pcs. - polymeric containers (1) - cardboard packs.
  • 20 pcs. - polymeric containers (1) - cardboard packs.
  • 30 pcs. - polymeric containers (1) - cardboard packs.
  • 50 pcs. - polymeric containers (1) - cardboard packs.
  • 4 things. - contour cell packages (2) - cardboard packs.
  • 4 things. - contour cell packages (3) - cardboard packs.
  • 4 things. - contour cell packages (4) - cardboard packs.
  • 4 things. - contour cell packaging (5) - cardboard packs.

Pharmacological action of the drug tinidazole

Instructions for the drug Tinidazole
Instructions for the drug Tinidazole

Antiprotozoal agent with antibacterial action. Active against Trichomonas vaginalis, Entamoeba histolytica, Lamblia intestinalis. The mechanism of action is due to the inhibition of synthesis and damage to the DNA structure of pathogens.

Has a bactericidal effect against the following anaerobic bacteria: Bacteroides spp. (including Bacteroides fragilis, Bacteroides melaninogenicus), Clostridium spp., Eubacterium spp., Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp., Veillonella spp.

Pharmacokinetics of the drug tinidazole

Tinidazole is highly absorbed, bioavailability is about 100%. Plasma protein binding - 12%. Cmax after oral administration of 2 g is achieved after 2 hours and is equal to 40-51 μg / ml, after 24 hours it is 11-19 μg / ml, after 72 hours - 1 μg / ml. Vd - 50 liters. Penetrates the BBB and the placental barrier.

Excreted in breast milk within 72 hours after ingestion.

It is metabolized in the liver to form pharmacologically active hydroxylated derivatives, which inhibit the growth of anaerobic microorganisms and can enhance the effect of tinidazole. T1 / 2 - 12-14 hours. 50% is excreted in the bile, the kidneys are excreted 25% (unchanged) and 12% (in the form of metabolites) due to reabsorption in the renal tubules.

Indications for the use of the drug tinidazole

The drug is used in the treatment of infections.

Instructions for the drug Tinidazole
Instructions for the drug Tinidazole

Infections caused by anaerobic bacteria, such as:

  • peritonitis, abscess;
  • gynecological infections;
  • sepsis;
  • wound infections after surgery;
  • infections of the skin and soft tissues;
  • respiratory system infections;
  • nonspecific vaginitis;
  • acute ulcerative gingivitis;
  • trichomoniasis of the genitourinary system, both in women and in men;
  • giardiosis (giardiasis);
  • intestinal amebiasis;
  • amoebic liver abscess;
  • Helicobacter pylori infection with gastric ulcer and duodenal ulcer, in combination with other drugs;
  • for the prevention of postoperative infectious complications caused by anaerobes, especially after operations on the colon, stomach and intestines, as well as gynecological operations.

Contraindications to the use of the drug tinidazole

There are contraindications to the use of tinidazole.

Instructions for the drug Tinidazole
Instructions for the drug Tinidazole

When to avoid taking tinidazole:

  • if the patient has an allergy (hypersensitivity) to tinidazole, 5-nitroimidazole derivatives or any of the other components of the drug tinidazole;
  • in a patient with a neurological disease;
  • if the patient currently or has had any changes in the blood picture in the past;
  • in the first trimester of pregnancy;
  • during lactation.

If neurological disorders occur during treatment with tinidazole, such as dizziness, ataxia (impaired coordination), peripheral neuropathy (for example, decreased sensitivity and muscle strength, muscle atrophy), it is necessary to stop treatment with tinidazole and consult a doctor immediately.

During treatment and at least for 3 days after the end of treatment with tinidazole, alcoholic beverages should not be consumed, as the so-called disulfiramic reaction may occur (the symptoms of which are: abdominal pain, vomiting, heart palpitations, hot flashes).

Use of tinidazole during pregnancy and lactation

Contraindicated for use in the first trimester of pregnancy.

Instructions for the drug Tinidazole
Instructions for the drug Tinidazole

Application in the II and III trimesters is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus. If necessary, use during lactation should decide on the termination of breastfeeding. Tinidazole is determined in breast milk within 72 hours after ingestion.

Instructions for the use of the drug tinidazole in men

The drug tinidazole is successfully used to treat men with diseases such as lambiosis and trichomaniasis of the genitourinary system.

Instructions for the drug Tinidazole
Instructions for the drug Tinidazole

Doses and method of administration of the drug tinidazole in men:

  • trichomoniasis: if infection is confirmed, simultaneous treatment of both sexual partners is indicated. Take 2 g of tinidazole (4 tablets of 500 mg) once.
  • lambiosis: take 2 g of Pinidazole (4 tablets of 500 mg) once.

Also, the drug tinidazole can be taken by men according to the instructions for use of the drug tinidazole. After taking the tablets, do not drive a car or engage in other activities that require concentration. Tinidazole causes lethargy and decreased response.

Dosage and administration of tinidazole

Instructions for the drug Tinidazole
Instructions for the drug Tinidazole

Usually, the following dose of the drug is taken:

  • Infections caused by anaerobic bacteria: adults: on the first day, 2 g (4 tablets of 500 mg) of the drug in a single dose, and then 1 g (2 tablets of 500 mg) per day in a single dose or in 2 divided doses. The duration of treatment is usually 5 to 6 days, but some patients may require longer treatment. If treatment is indicated for more than 7 days, the doctor will order regular examinations, including blood tests. Children under 12 years of age: Dosage not established.
  • Nonspecific vaginitis: adults: 2 g of tinidazole (4 tablets of 500 mg) once. Significant treatment efficacy was observed after taking 2 g of tinidazole (4 tablets of 500 mg) per day in a single dose for 2 days (total therapeutic dose: 4 g).
  • Acute ulcerative gingivitis: adults: 2 g of tinidazole (4 tablets of 500 mg) once. If the patient has a suspicion that the effect of the drug is too strong or, on the contrary, insufficient, you should consult a doctor. Do not change the dosage of the drug yourself.
  • Trichomoniasis: If infection is confirmed, simultaneous treatment of both sexual partners is indicated. Adults: 2 g tinidazole (4 tablets of 500 mg) as a single dose. Children: 50 to 75 mg / kg body weight as a single dose. The dose can be repeated if necessary.
  • Giardiosis (giardiasis): adults: 2 g of tinidazole (4 tablets of 500 mg) once. Children: 50 to 75 mg / kg body weight as a single dose.
  • Intestinal amebiasis: adults: 2 g of tinidazole (4 tablets of 500 mg) per day in a single dose for 2 or 3 consecutive days. If necessary, the doctor can extend the treatment up to 6 days. Children: 50 to 60 mg / kg body weight per day in a single dose for 3 consecutive days.
  • Amebic liver abscess: adults: depending on the severity of the infection, 4.5 to 12 g of tinidazole for the entire course of treatment. Lancing of an abscess may be indicated in some patients, regardless of tinidazole treatment. Treatment begins from 1.5 to 2 g per day, in a single dose, for 3 days. If necessary, the doctor can extend the treatment up to 6 days. Children: 50 to 60 mg / kg body weight per day in a single dose for 5 consecutive days.
Instructions for the drug Tinidazole
Instructions for the drug Tinidazole
  • Helicobacter pylori infection in gastric ulcer and duodenal ulcer: adults: Tinidazole is taken in a dose of 500 mg twice a day for 7 days in combination with another antibacterial drug and omeprazole (a drug that reduces the acidity of gastric juice). The following dosing regimen is recommended: tinidazole 500 mg twice daily, clarithromycin 250 mg twice daily, and omeprazole 20 mg twice daily for 7 days.
  • Prevention of postoperative infections: adults: 2 g of tinidazole (4 tablets of 500 mg) once, approximately 12 hours before surgery. Children under 12 years of age: Dosage not established. Elderly patients: there are no special instructions regarding dosing.

Side effects of the drug tinidazole

Also, when using the drug tinidazole, there may be side reactions of the body to the drug.

Instructions for the drug Tinidazole
Instructions for the drug Tinidazole

During the use of the drug Tinidazole, the following side effects are observed:

disorders of the gastrointestinal tract: nausea, vomiting, lack of appetite, diarrhea, abdominal pain, coated tongue, glossitis, stomatitis.

Nervous system disorders: dizziness, headache, ataxia (lack of coordination), decreased tactile sensitivity, peripheral neuropathy (eg, decreased sensitivity and muscle strength, muscle atrophy), rarely - convulsions, sensory disturbances, metallic taste in the mouth, sudden redness skin. If these symptoms occur, you must stop using the drug and consult a doctor.

If any undesirable effect intensifies or if other adverse reactions occur that are not listed in this leaflet, notify your doctor.

Violations of the skin and subcutaneous tissue: hypersensitivity reactions, sometimes with a severe course, rarely occur, can manifest themselves in the form of a rash, urticaria or angioedema (swelling of the face, tongue and trachea, which causes respiratory distress). If they appear, you must immediately consult a doctor.

Disturbances from the blood and lymphatic system: a transient decrease in the content of leukocytes in the blood.

Disorders from the kidneys and urinary tract: dark staining of urine, mycosis of the urinary tract.

General disorders and condition at the injection site: fever, fatigue.

Interaction with other medicinal products

You should inform your doctor about all recently taken medications, even those sold without a prescription.

Instructions for the drug Tinidazole
Instructions for the drug Tinidazole

The doctor should be informed about: alcohol consumption (the possibility of the onset of the so-called disulfiramic reaction); on the use of anticoagulants (drugs that inhibit the process of blood coagulation, used for thromboembolic diseases).

Tinidazole is compatible with sulfonamides and antibiotics (rifampicin, erythromycin, aminoglycosides, cephalosporins). Its metabolism is accelerated with the simultaneous use of phenobarbital.

It is not recommended to use ethionamide during treatment. The drug increases the effect of indirect anticoagulants. To reduce the risk of bleeding, the dose should be halved. Tinidazole enhances the effect of ethanol.

Special instructions when using the drug tinidazole

There are special instructions for the use of tinidazole in the instructions of the drug.

Instructions for the drug Tinidazole
Instructions for the drug Tinidazole

Special instructions when using the drug tinidazole:

  • when treating trichomoniasis, simultaneous treatment of both partners should be carried out;
  • in the event of adverse reactions from the central nervous system, tinidazole should be canceled;
  • during treatment, one should refrain from drinking alcohol;
  • when using tinidazole, dark coloration of urine is observed;
  • if treatment lasts more than 6 days, regular monitoring of the peripheral blood picture should be carried out;
  • for the prevention of postoperative anaerobic infections, the dose for children under 12 years of age has not been established;
  • during the period of treatment, patients should refrain from engaging in potentially hazardous activities that require increased attention and high speed of psychomotor reactions.

Driving and maintenance of machinery: there is no information indicating a contraindication to driving and maintenance of machinery during the use of tinidazole.

However, some patients have experienced undesirable effects, such as dizziness, seizures, or impaired sensation in the limbs, which can impair psychophysical performance. With the appearance of such undesirable effects, it is impossible to drive a vehicle and maintain working mechanisms.

Analogues of the drug tinidazole

Instructions for the drug Tinidazole
Instructions for the drug Tinidazole

Tinidazole analogs are the following drugs: Tinib; Tinidazole-Acri; Fazizhin; synonyms and drugs of the trichopol group.

Price, conditions and shelf life of the drug tinidazole

The drug is stored in a dry, dark place at a temperature of 15 to 5 degrees Celsius. Subject to the storage conditions, the drug is suitable for three years.

Its exposure to many different parasites and its low cost makes Tinidazole very popular. But only a doctor should prescribe it. Then it will be possible not only to quickly cure the body, but also to avoid the consequences of improper intake of the drug.

The price of tinidazole is quite reasonable. Depending on the region, it can cost in the range from 20 to 100 rubles. And this is a definite plus, since the availability of a drug in our country often determines a person's adherence to treatment. Tinidazole, and an analogue of which can be bought at the pharmacy, is popular with doctors and patients.

Find out more:

  • Furazolidone: indications and instructions for use
  • Trichopol - instructions for use, indications
  • Metronidazole - instructions for use and indications

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