Furazolidone: Indications And Instructions For Use

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Furazolidone: Indications And Instructions For Use
Furazolidone: Indications And Instructions For Use

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Furazolidone is a well-known drug used mainly for diseases of the genitourinary system. It is used for diseases such as cystitis, urethritis, giardiasis, Trichomonas colpitis, etc. Furazalidone has shown excellent results in the treatment of these diseases. Furazalidone is available in tablets, instructions for its use describe in detail the dosage regimen and the method of using the drug.

The content of the article:

  • 1 Furazolidone: pharmacological properties
  • 2 In what cases is Furazolidone used
  • 3 Indications
  • 4 Release form
  • 5 Instructions for use
  • 6 Doses of taking the drug by age and disease
  • 7 Side effects
  • 8 Contraindications
  • 9 Interaction with other medicinal products
  • 10 Taking Furazolidone during pregnancy
  • 11 Analogs
  • 12 The combination of furazolidone with other drugs
  • 13 Price

Furazolidone: pharmacological properties

The pharmacological action of the drug is well described by the instructions for the use of Furazolidone, available to everyone. The drug is effective in the therapeutic treatment of a variety of acute and common inflammatory processes that are caused by existing aerobic gram-negative bacteria.

Instructions for Furazolidone tablets
Instructions for Furazolidone tablets

Furazolidone is the main synthetic derivative of nitrofurforol. Its effective pharmacological properties depend on the dose taken by a sick person. With a small dosage, the drug has a proper, effective bacteriostatic effect. If the dose is increased within reasonable limits, then the medication begins to provide the bactericidal effect necessary for the patient.

The pre-microbial effect is mainly based on the direct restoration of nitro groups under the influence of special enzymes in the body. Certain nitro groups included in the composition of the drug are reduced to the necessary amino groups, which become highly toxic for a variety of negative microorganisms.

Such certain amino groups violate the integrity of the bacterial cell membrane and block further processes in the cell itself. As a result, negative microorganisms lose their own ability to reproduce further.

The drug also has a small stimulating effect required in treatment. Furazolidone actively promotes the phagocytic activity of leukocytes, but also increases the susceptibility of the sick person's body to ethyl alcohol. If the medication is taken with alcohol, then severe vomiting and unpleasant nausea may occur.

Instructions for Furazolidone tablets
Instructions for Furazolidone tablets

After oral administration, the drug is rapidly absorbed in the desired parts of the intestine. The therapeutic concentration in the blood plasma is maintained for six hours after taking the drug, which is a fairly long time.

Instructions for use of the drug describe in sufficient detail what the Furazolidone tablets help from in the first place. The use of a drug in the treatment of various inflammatory and infectious diseases of the genitourinary system is entirely justified. Also, this medication effectively fights various diseases of the skin, stomach and intestines.

In what cases is Furazolidone used

The drug has proven efficacy against a number of protozoa and is used for infections caused by some gram-positive and gram-negative microorganisms, with the exception of pathogens of anaerobic and purulent inflammatory processes.

It is effective in the food type of toxicoinfections, paratyphoid fever, bacillary dysentery, giardiasis, infections of the genitourinary tract (pyelitis, cystitis, urethritis) caused by Trichomonas, as well as in the treatment of burns and infected skin surfaces in operative medicine.

Indications

  • diarrhea;
  • bacillary dysentery;
  • infectious enteritis;
  • paratyphoid;
  • urethritis;
  • lambiosis;
  • Trichomonas colpitis;
  • vaginitis;
  • cystitis;
  • infected wounds;
  • pyelitis.

Release form

Instructions for Furazolidone tablets
Instructions for Furazolidone tablets

The medication is produced in tablets that have a yellow or yellow-green color, flat-cylindrical shape and chamfer. Each pill for abdominal pain is packaged in a contoured, cell-free package of ten pieces and placed in a cardboard box of one or ten packages, supplied with a leaflet with instructions. Tablets can also be packaged in a blister strip and placed in a cardboard box one, two, five, fifty or one hundred packs at a time, accompanied with a foldable instruction.

Each tablet contains fifty milligrams of the active substance furazolidone, as well as a certain amount of excipients of lactose monohydrate, colloidal anhydrous silicon dioxide, calcium stearate, potato starch.

Instructions for use

Now let's talk about how to take Furazolidone. According to the instructions, the medicine is taken orally. The tablet is swallowed whole and washed down with water. It is necessary to drink the product with a very large amount of water.

  • For various food intoxications and dysentery, 100-150 mg is used. The course of drug treatment is 7-10 days. The treatment of diarrhea with Furazolidone is also carried out.
  • In the presence of acute Trichomonas infection, 100 mg of the drug is prescribed for three days 3-4 times a day. Also, Furazolidone powder is injected into the vagina, after diluting the medication with water. To enter the rectum, rectal suppositories with Furazolidone are used.
  • With urethritis, take 100 mg of the drug 4 times a day for 3 days.
  • A particular disease is giardiasis. In the presence of this disease, the doctor prescribes for adults 100 mg of the drug 4 times a day. Children - 10 mg per 1 kg of body weight. The daily dose is divided into three doses.
  • Furazolidone is used in the treatment of infectious wounds and burns. Wet dressings with a drug, irrigation with a solution of Furazolidone are used.
  • Furazolidone for cystitis is used in two tablets (this is 100 mg) four times a day after meals, for three to six days.
Instructions for Furazolidone tablets
Instructions for Furazolidone tablets

Doses of taking the drug by age and diseases

In basic therapy, the drug is administered orally after a meal. Furazolidone must be taken with a sufficient amount of liquid. In surgical practice, local forms of exposure to the affected surface are often used. The course of therapy is 7-10 days.

Diseases of the gastrointestinal tract of infectious etiology Parasitic infections Urinary tract and urogynecological diseases Application in surgical practice
The course of treatment is from 5 to 10 days, 2-3 tablets 4 times a day, the maximum total dose per day is 16 tablets Adults are prescribed 2 tablets 4 times a day, the dosage for children is calculated depending on body weight: 10 mg per 1 kg of weight, the total dose is also divided into 4 doses 2 tablets 3-4 times a day. The course of therapy - 3 days A solution of the drug is used in the form of local irrigation or as part of lotions

Side effects

The drug is of little toxicity. However, it can also lead to a variety of side effects. There may be special discomfort in the gastrointestinal tract, nausea, vomiting, sharp or dull pain in the abdominal cavity, lack of appetite.

Possible manifestations of an allergic reaction, pruritus, Quincke's edema, rash, urticaria.

Doctors recommend taking B vitamins in conjunction with taking Furazolidone. To prevent unwanted side effects, the drug must be taken with plenty of water and at the same time taken antihistamines. This will avoid unwanted allergic reactions to the medication.

Contraindications

Instructions for Furazolidone tablets
Instructions for Furazolidone tablets

The drug has a number of minor contraindications. It is necessary to stop taking the drug if the patient suddenly becomes hypersensitive to the drug itself or to its components. The use of Furazolidone is not recommended for chronic renal failure, as well as for lactose deficiency.

Take the medicine with extreme caution if there are diseases of the nervous system, since the medicine affects concentration. Therefore, it is better for drivers to refrain from taking medication.

Interaction with other medicinal products

Reviews of the drug describe the possible interaction of the drug with other drugs.

The antibacterial activity of Furazolidone is significantly increased with the simultaneous administration of this drug with aminoglycosides and tetracyclines.

There is also a high risk of inhibition of hematopoietic functions when taking Furazolidone with Ristomycin, Chloramphenicol. Do not take this medication together with medications such as Ephedrine, Amphetamine.

Taking Furazolidone during pregnancy

Instructions for Furazolidone tablets
Instructions for Furazolidone tablets

The effect of this medication on the bearing of a fetus during pregnancy has not yet been fully studied by pharmaceutical scientists. Clinical studies on some pregnant women have shown that in the first trimester of pregnancy, taking Furazolidone does not have a particular negative effect on the pregnant fetus and does not significantly increase the risk of any malformations of the unborn child.

In pregnant women who have to give birth to a child with a deficiency of glucose-6-phosphate dehydrogenase, clinical studies have shown that the fetus may develop hemolytic anemia when taking Furazolidone.

Attention! It is considered acceptable to use Furazolidone during pregnancy under close medical supervision. Before taking this drug, it is imperative that you consult with your doctor!

You need to know which drugs have a particular negative effect on the further course of pregnancy and on the development of the fetus, and which do not. Many medications should not be taken during pregnancy, as they can develop some dangerous diseases in the unborn child.

A certain substance in a component of any medicine has a special effect on the development of all systems of the fetus's body. Medicines during pregnancy should be prescribed only by the attending physician who is well aware of all the characteristics of the organism of the expectant mother and is constantly monitoring the development of the fetus. Consultation with your doctor during pregnancy is mandatory and will avoid any negative consequences.

Analogs

Instructions for Furazolidone tablets
Instructions for Furazolidone tablets

According to the active substance, Furazolidone has practically no analogues. But in the treatment of some acute diseases of the genitourinary system and various diseases of the gastrointestinal tract, you can use the following drugs:

  • vaginal suppositories Betadine;
  • pessaries Betadine;
  • pessaries Betayod-Pharmex;
  • vaginal pessaries Vokadin;
  • vaginal suppositories Geksikon;
  • vaginal tablets Ginaflor;
  • vaginal suppositories Depantol;
  • vaginal tablets Klioron;
  • vaginal tablets Colposeptin.

The combination of furazolidone with other drugs

Instructions for Furazolidone tablets
Instructions for Furazolidone tablets

Antibiotics of the tetracycline group and aminoglycosides are used in combination therapy, as they increase the effect of furazolidone on pathogenic microorganisms.

Preparations of antidepressant groups, other MAO inhibitors, phenylephrine, amphetamine, ephedrine-containing drugs in combination with nirofurans provoke an increase in blood pressure.

Alcohol-based drugs and alcoholic beverages, when taken simultaneously with nitrofuran derivatives, cause disulfamiropod-like reactions, accompanied by fever, blood flow to the head, a drop in blood pressure, tachycardia, nausea, and panic attacks.

Price

The cost of Furazolidone may vary somewhat in a different price range in different domestic pharmacies. The price is influenced by the initial cost of the medicine from the manufacturer, the availability of analogues, the use of cheap or expensive raw materials in the production of the medicine. The average cost of Furazolidone in domestic pharmacies is from 60 rubles.

Furazolidone is a massively available and widely used drug. It is especially effective in treating acute diarrhea in adults and children. It has the maximum effect on harmful bacteria in the gastrointestinal tract and in the genitourinary system.

That is why this medicine is actively used in the treatment of cystitis, vaginal infections, paratyphoid fever, food intoxication. But it is important to know how to give Furazolidone. The main thing is to drink the drug with a large amount of liquid - plain water. Also, Furazolidone solution is used to treat complex infectious wounds.

Instructions for Furazolidone tablets
Instructions for Furazolidone tablets

Due to the risk of developing concomitant diseases when taking Furazolidone, it is required to exclude from the diet those foods that are rich in tyramine - hard cheeses, chocolate, etc.

Due to the risk of developing concomitant diseases when taking Furazolidone, it is required to exclude from the diet those foods that are rich in tyramine - hard cheeses, chocolate, etc. Furazolidone is prescribed with extreme caution to young children, pregnant women and lactating women. In general, Furazolidone is well tolerated by sick people and is a low-toxic drug.

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