Piperazine - Instructions For Use, Indications And Dosage

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Piperazine - Instructions For Use, Indications And Dosage
Piperazine - Instructions For Use, Indications And Dosage

Video: Piperazine - Instructions For Use, Indications And Dosage

Video: Piperazine - Instructions For Use, Indications And Dosage
Video: PH20 Antiprotozoal and Antihleminthic Drugs 2024, March
Anonim

Piperazine is a drug used to treat helminthic infestations. Piperazine is prescribed for both children and adults. The drug is effective against ascaris and pinworms, which are the most common types of helminths in humans.

The content of the article:

  • 1 What is Piperazine
  • 2 How Piperazine works
  • 3 Pharmacological action
  • 4 Pharmacodynamics and pharmacokinetics
  • 5 Indications for the use of Piperazine

    • 5.1 For adults
    • 5.2 For children
    • 5.3 For pregnant women and during lactation
  • 6 Contraindications
  • 7 Side effects
  • 8 Piperazine for children
  • 9 Piperazine: Tips for Use for Children and Adults
  • 10 How to use the drug
  • 11 Analogs
  • 12 Special instructions
  • 13 Overdose
  • 14 Storage conditions
  • 15 Price

What is Piperazine

The human intestine produces many essential enzymes for the normal functionality of the entire system. Their absence has a detrimental effect on the functioning of the body as a whole.

Piperazine
Piperazine

For the destruction of parasites, antihelminthic drugs are used. The following symptoms of helminthiasis infection may occur:

  • headache;
  • sleep disturbance;
  • naughty nerves;
  • constant jumps in weight;
  • bloating;
  • joint pain.

Piperazine tablets are a chemical derived from ammonia. Its range of applications ranges from the pharmacological line of production of analgesics, antispasmodics and psychotropic substances to industry as an accelerator of rust formation. In medicine, it is better known as an antihelminthic drug. It is considered non-toxic, because it does not "dissolve" nematode worms, but only paralyzes them.

When applied, the drug acts on both sexually mature worms of both sexes and immature ones. However, it does not always cope with eggs in a state of migration, if nematodes have spread far beyond the intestines. Previously, the drug was dispensed exclusively by prescription, now the situation is different.

But even if you are ashamed that somehow you have become infected, it is better to seek the advice of a specialist. When prescribing a dosage, the doctor will take into account the specifics of your body, conduct laboratory tests.

How does piperazine work

Piperazine
Piperazine

Piperazine is widely used for the treatment of enterobiasis and ascariasis. It is active against nematode worms; upon contact with the drug, complete paralysis of the muscles of the parasites occurs due to the blocking of the transmission of the neuromuscular impulse. In this case, the worms do not die, which excludes the possibility of poisoning the body with toxins formed during the decomposition of dead roundworms and other helminths.

The worms lose the ability to attach to the intestinal walls and are gradually excreted. The toxicity of the drug itself is minimal; according to doctors' reviews, it is considered one of the safest means for deworming. Piperazine adipate has no structural analogs for the active component.

pharmachologic effect

Piperazine
Piperazine

Piperazine is a synthetic, narrowly targeted antihelminthic agent. The drug has a detrimental effect on enterobiasis, ascariasis. The active ingredient acts on the muscular apparatus of parasites, completely paralyzes their motor activity. With the correct dosage, a large number of parasites are removed at one time.

Pinworms and roundworms are more sensitive to the drug. The rest of the types of worms are not amenable to this drug, so another remedy is used to treat other types of parasites.

Pharmacodynamics and pharmacokinetics

Piperazine
Piperazine

Piperazine is almost completely absorbed into the bloodstream, but its bioavailability has not yet been studied. The active substance is not concentrated in the tissues, it acts only in the intestine, while it does not cause complete death of parasites, but only paralyzes their locomotor apparatus, in this case, helminths do not emit poison at the time of injury.

The drug crosses the placenta and passes into breast milk. The substance settles in the liver, is excreted in the urine during the day. If a person suffers from hepatic or renal failure, the time it takes to withdraw the drug from the body increases.

Indications for the use of Piperazine

The drug is used for ascariasis, enterobiasis.

For adults

Piperazine is often used by patients of this age group to eliminate and remove worms. The composition is not broadly effective.

Piperazine
Piperazine

The greatest results can be achieved in the treatment of enterobiasis. The dosage of the medicinal composition is determined individually by specialists. The recommended amount of the composition depends on the severity of the lesion and the nature of the course of the disease. The duration of the course of exposure is also determined on an individual basis.

For kids

Piperazine is a highly safe anthelmintic drug. The remedy, if indicated, can be prescribed to children starting from the neonatal period.

The recommended dosages are based on the age and weight of the child. The optimal regimen is privately approved.

In most cases, the composition is well tolerated. Adverse reactions during the use of the drug are extremely rare.

For pregnant women and during lactation

Clinical trials that can confirm the safety of taking the composition by women during pregnancy have not been conducted, however, the manufacturer of the product does not regulate strict prohibitions on the use in this interval. The composition can be used if there are indications for a limited course. The dosage for a woman should be determined privately by the attending physician.

Contraindications

Despite the fact that the drug is practically non-toxic, if the correct dosage is observed, it is not prescribed to all patients. Unlike other anthelmintic drugs, Piperazine for worms has few contraindications, and can even be prescribed to pregnant women and children, but in this case it is necessary to consult a doctor.

Piperazine
Piperazine

It is not recommended to take the medicine for children under three years old (this applies to taking pills, the injection is allowed only under the supervision of a doctor and only in certain cases).

If patients have a high sensitivity to the components of the drug or intolerance, it should also not be taken, otherwise unwanted allergic reactions may occur.

If a person has an organic lesion of the central nervous system, the medicine cannot be taken.

Piperazine is contraindicated for people with renal insufficiency, since the drug is excreted to a greater extent in the urine, in some cases it can only be taken under medical supervision.

Side effects

Piperazine in tablet form can be prescribed for both adults and children, since the drug is easily tolerated and practically does not cause side reactions. Side effects may occur if Chlorpromazine is also taken during the treatment period. If a person has side effects from this medication, then they may be mild in the form of mild nausea, minor headache, drowsiness, and when they are taken, the patient may have a stomach ache.

Piperazine
Piperazine

Rarely, if a person has kidney pain, the drug can cause poisoning. If the patient suffers from severe renal failure, tremors of the extremities, hallucinations may begin, vision may temporarily deteriorate, coordination of movement may be impaired, muscle weakness may also occur, which is expressed in such a state of a person when he wants to lie down or the person gets tired for no reason.

If side reactions in a person are weak, then the drug is not canceled and the patient undergoes a full course of treatment. If a person has severe adverse reactions, it is necessary to stop taking the medication and eliminate the symptoms. In this case, the doctor must select a similar drug.

Adverse reactions in case of an overdose may manifest in limb tremors, muscle weakness, severe nausea, abdominal and head pain, vomiting, diarrhea or constipation.

It is necessary to treat such symptoms by removing toxins from the body. The patient needs to take sorbents, sometimes the patient is prescribed laxatives, since this drug may cause constipation. If severe drug poisoning occurs, you must put a dropper or inject Thiamine.

Piperazine for children

With ascariasis, children of the first year of life are shown taking 0.2 grams of Piperazine 2 times a day. Babies from 2 to 3 years old are prescribed 0.3 grams of the drug per appointment. Small patients 4-5 years old need to take 1 gram per day (the dose is divided into 2 doses). Children from 6 to 8 years old are shown taking 0.75 g twice a day.

Piperazine
Piperazine

For children and adolescents up to 12 years of age inclusive, a daily dose of 2 g is recommended. Adolescents from 13 to 15 years old should take a dose that is almost the same as the "adult" dose, that is, 3 grams per day. According to another scheme, children should take from 0.4 grams once.

Enterobiasis suggests similar doses, but longer (up to 5 days) therapy. It may take from 1 to 3 courses with a weekly interval between them.

Piperazine: Tips for Use for Children and Adults

If the patient has a tendency to constipation, then it is better to take laxatives during treatment with Piperazine, as this drug can cause constipation.

Before taking Piperazine, you do not need to follow a specific diet or give up any type of food or nutrition in general.

It is best if the doctor prescribes the treatment with such a remedy and sets the dosage, however, if the patient was previously given a dosage and was treated with Piperazine, it can be taken again without a specialist's warning.

How to use the drug

Any dosage form of Piperazine is intended for oral administration. The expulsion of ascaris from the intestine requires a dose of 1.5-2 grams. The maximum daily dosage should not exceed 4 grams. The frequency of admission is twice a day. It is advisable to take an anthelmintic agent one hour before meals or half an hour to an hour after.

Piperazine
Piperazine

In the treatment of pinworm infection, the amount of the drug per intake is the same, but the course therapy is carried out for 5 days.

The time intervals between courses should be 1 week (up to three courses may be required). In the period between courses, patients are shown at night enemas (200-600 ml of water + 1/2 tablespoon of baking soda for every 200 ml). The procedure is needed to expel pinworms from the lower intestines.

When treating ascariasis, an enema is given only after the end of treatment. Therapy for helminthic invasions is carried out on an outpatient basis, i.e. at home. Therapy of enterobiasis involves the strictest adherence to hygiene standards in order to avoid re-infection.

The duration of the course of treatment is 2 days. An alternative regimen involves a single dose of 4 grams of Piperazine or the consumption of 2 grams of the drug 2 times.

Analogs

  • Pirantel is an effective anthelmintic drug that kills worms and removes them outside. Pirantel destroys the eggs of the worm, as well as those worms that lead to the development of anemia. The medicine fights against such types of worms as human roundworm, pinworms. The active substances of the drug block the motor ability of worms, after which they die. Pirantel has contraindications, so the dosage should only be selected by a doctor.
  • Vermox - the medicine is prescribed for ascariasis, enterobiasis. The drug has a wide antimicrobial spectrum of action for helminthic invasions. It is prescribed for both adults and children.
  • Phytogistocide - the remedy is used for all types of helminthic diseases, helps to restore the functioning of the digestive tract, liver and pancreas. Relieves inflammation, replenishes the body with vitamins, minerals, flavonoids, essential oils.
  • Zentel - used in the case when a person has a severe form of worm diseases, accompanied not only by infection with worms, but also by inflammatory processes that cause parasites in the course of their life. The drug is effective for opisthorchiasis, giardiasis, trichocephalosis, teniasis.
  • Nemozol is a modern antihelminthic drug that eliminates enterobiasis in the shortest possible time, destroys all types of worms, and also helps to cope with diseases such as opisthorchiasis, clonorchiasis. The drug is prescribed for adults and children. Before use, you must read the instructions, since the medicine is quite strong in its effect.

special instructions

Piperazine
Piperazine

Taking the drug does not require special preparation and special dietary nutrition. Patients with a predisposition to constipation are advised to take saline laxatives on the days of taking the drug. In the treatment of helminthic lesions, the main goal is to maintain a hygienic regime.

Overdose

The likelihood of overdose when using the composition in regulated doses is minimal. It is not recommended to use the composition for a long course due to the presence of the risk of addiction of pathogens to the active component.

Storage conditions

The drug, produced by pharmaceutical companies in the form of tablets, should be stored at a temperature of no more than 25 degrees in a dry place, protected from the access of children. The shelf life does not exceed 2 years from the date of production. It is forbidden to use the product after this time.

Price

The drug is dispensed without a prescription, applied according to the instructions. This means you can order and buy it from an online store or pharmacy without a doctor's prescription.

Piperazine's price varies by region of Moscow. The most inexpensive for today is the one that is sold at a cost of 13 rubles. And at the highest price it can be bought in Tyumen - for 41 rubles.

In the catalog of an online store in Moscow, you can order medicine relatively inexpensively, on average for 19 rubles.

Find out more:

  • Nemozol - instructions for use, indications and dosage
  • Pirantel: suspension for children from worms - application
  • Parasites in the human body: symptoms and treatment

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