Table of contents:
- Albendazole / Albendazole
- pharmachologic effect
- Albendazole, indications for use
- Method of administration and dosage
- Side effects
- Drug interactions
- Storage conditions
- Special instructions and precautions
- Albendazole suspension 10%, vial 1 l
- Medicines for animals: Albendazole (powder, tablets)
Video: Albendazole For Worms: Instructions For Use
2023 Author: Riley Dean | [email protected]. Last modified: 2023-11-27 09:15
Albendazole is a wonderful drug that effectively removes parasites. Before starting treatment with this drug, you should read the instructions for use and consult your doctor.
The content of the article:
- 1 Albendazole / Albendazole
- 2 Pharmacological action
- 3 Albendazole, indications for use
- 4 Contraindications
- 5 Pregnancy
- 6 Method of administration and dosage
- 7 Side effects
- 8 Drug interactions
- 9 Overdose
- 10 Storage conditions
- 11 Special instructions and precautions
12 Albendazole suspension 10%, vial 1 l
- 12.1 Composition and form of release
- 12.2 Pharmacological properties
- 12.3 Indications
- 12.4 Doses and method of administration
- 12.5 Side effects
- 12.6 Contraindications
- 12.7 Special instructions
- 12.8 Storage conditions
- 13 Medicines for animals: Albendazole (powder, tablets)
Albendazole / Albendazole
Composition and form of release
1 tablet of Albendazole contains albendazole 0.4 g;
in the package 3 pcs.
The drug Albendazole exhibits anthelmintic activity. Albendazole affects the polymerization of β-tubulin, stops it. As a result, there is a violation of the formation of microtubules in the intestines of helminths, the ability of worms to absorb glucose is suppressed, the normal intracellular migration of organelles, the synthesis of ATP in their muscle tissue is blocked. The creation of a therapeutic concentration of albendalosis leads to the death of helminths.
Active against adults and larval forms. The drug causes the death of nematodes (Necator americanus, Strongyloides stercoralis, Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Cutaneous Larva Migrans, Ancylostoma duodenale), cestodes (porcine, bovine and dwarf tapeworms), trematodes (Clonorchistis viperrini)).
Albendazole, indications for use
Albendazole is prescribed for:
- echinococcosis of the peritoneum, liver, lungs;
- contraindications to surgery for cystic echinaccoccosis;
- the need for surgical intervention for cystic echinaccoccosis to reduce the number of cysts;
- arachnoid, intragastric, racemose cysts;
- mixed helminthiasis.
Albendazole is not prescribed for:
- helminthiasis in children under 2 years of age;
- hypersensitivity to albendazole;
Albendazole is strictly contraindicated in pregnancy, suspected pregnancy
With caution when:
- retinal pathologies against the background of cysticercosis;
- cirrhosis of the liver;
- oppression of bone marrow hematopoiesis.
Albendazole is categorically contraindicated in pregnancy, suspected pregnancy.
Method of administration and dosage
Albendazole is prescribed orally, after meals. The tablets are washed down with water. The table shows dosages depending on the pathology. Taking laxatives after taking Albendazole is not necessary.
|Dosage per day||Amount of days|
|Common helminthiasis||400 mg (children - 60 mg / 10 kg)||Disposable|
|Cysticercosis of the brain||800 mg (children - 15 mg / kg)||8-30 days|
|Strongyloidosis and cestodosis||400 mg (200 mg)||3 days with repetition after 3 weeks|
|Ascariasis||400 mg (200 mg)||One-time with repetition after 3 weeks|
|Enterobiasis||400 mg (200 mg)||One-time with repetition after 3 weeks|
|Ankylostomiasis||400 mg (200 mg)||One-time with repetition after 3 weeks|
|Giardiasis||400 mg (200 mg)||3 days with repetition after 3 weeks|
Taking Albendazole may be accompanied by undesirable effects:
- increased activity of liver transaminases;
- stomach pain;
- meningeal symptoms;
- itchy skin;
- alopecia (reversible);
- impaired renal function.
Dexamethasone, praziquantel, and cimetidine increase the concentration of albendazole in the blood. An increase in the concentration of albendazole in the bile and in the contents of the echinococcal cyst was found when used simultaneously with cimetidine, which can increase the effectiveness of the treatment of echinococcosis.
Excessive doses are characterized by an increase in side symptoms.
Storage is carried out under standard conditions (low room humidity, room temperature). Shelf life is 3 years.
Special instructions and precautions
Albendazole is prescribed with caution to patients with inhibition of bone marrow hematopoiesis, liver failure, liver cirrhosis, pathology of the retina. Blood tests should be performed at the beginning of every 28 day cycle and every 2 weeks during albendazole therapy.
It is necessary to discontinue therapy with the development of leukopenia. It is possible to continue treatment with albendazole if the decrease in the total content of leukocytes and neurotrophilic leukocytes is moderate and does not progress.
Albendazole suspension 10%, vial 1 l
Composition and form of release
Anthelmintic preparation in the form of a suspension for oral administration, containing 10% albendazole and auxiliary components as an active ingredient. It is a suspension from white to pale cream in color with a characteristic odor. Produced in plastic bottles of 1 liter.
Patients receiving high doses of albendazole should be closely monitored, with constant monitoring of the state of liver function. In neurocysticercosis with eye damage, before starting treatment with albendazole, it is necessary to study the retina of the eye (the risk of aggravating its pathology).
Patients with neurocystocircosis should receive appropriate steroid therapy (GCS) and anticonvulsants. Oral or intravenous corticosteroids are used to prevent a hypertensive attack during the first week of anti-cyst therapy.
Albendazole, which is part of the drug, has a wide spectrum of anthelmintic action, is active against nematodes, trematodes and cestodes parasitizing in cattle. Albendazole is rapidly absorbed from the gastrointestinal tract. The maximum concentration of albendazole in the blood serum is observed 12-25 hours after the use of the drug.
The mechanism of action of albendazole is metabolic disturbance, inhibition of fumarate reductase activity and parasite ATP synthesis, which leads to the death of helminths. In terms of the degree of toxic effect on the body, it belongs to low-hazard substances, in the recommended doses it does not have a mutagenic, carcinogenic and local irritating effect. It is excreted from the body mainly with urine and bile.
Deworming of cattle in case of dictyocaulosis, hemonchosis, ostertagiasis, trichostrongylosis, nematodyrosis, cooperiosis, esophagostomosis, moniesiasis and fascioliasis.
Doses and method of administration
The drug is administered once orally using a syringe-dispenser, inserting the tip of the cannula into the corner of the lip and injecting the drug as deeply as possible. Shake the suspension bottle before use. In cattle with nematodes and cestodoses, the drug is administered at the rate of 0.75 ml for every 10 kg of animal weight, for fascioliasis - 1 ml for every 10 kg of animal weight.
With proper use and dosage, side effects are usually not observed. Intoxication due to overdose is practically impossible, since the safety limit exceeds 5 times the therapeutic dose.
The maximum tolerated dose for oral administration is 7.5 ml for every 10 kg of animal weight. If a higher dose is mistakenly administered, the animal may experience anorexia, sleeping sickness, weight loss, lethargy, and impaired gastrointestinal motility. In this case, you should stop the drug administration and apply symptomatic treatment.
Hypersensitivity to the drug. It is not allowed to use pregnant cows in the first third of pregnancy, as well as sick with infectious diseases and malnourished animals.
Slaughter of animals for meat is allowed no earlier than 14 days after the use of the drug.
The meat of animals that were forcedly killed before the expiration of the specified period can be used for feeding fur-bearing animals or for the production of meat and bone meal. Milk obtained from animals that have been treated with the drug must not be used for food purposes within 4 days after the use of albendazole. Such milk can be used to feed animals.
With precaution (list B). Store in a dry, dark place and out of the reach of children and animals at a temperature of 5 to 25 ° C. The shelf life is 3 years.
Medicines for animals: Albendazole (powder, tablets)
Brief description: Albendazole is a drug with a wide spectrum of antiparasitic activity, which is harmful not only for adult forms of parasites, but also for their larval stages and eggs. The drug is active against parasites that live in the intestines (nematodes, cestodes, trematodes, protozoa), as well as tissue forms (echinococcus, capillaria, gnatostom).
The drug is used for deworming animals and birds with dictyocaulosis, moniesiasis, bunostomoses, nematodirosis, strongylatosis, paramphistomiasis, cooperiosis, esophagostomosis, habertiosis, ascariasis, heterocytosis, fascioceliosis.
For whom: the drug can be prescribed to goats, sheep, cattle, fur-bearing animals, horses, pigs and poultry.
Form of dispensing: Albendazole is available in the format of a white-gray fine-grained powder containing 10% of the active ingredient, which is packed in 500 grams in polymer bags. Also, the drug is available in the form of rounded white or grayish tablets with an active ingredient content of 360 mg, 100 pieces in cardboard boxes.
Dosage: the drug is given to animals with food. The average therapeutic dose for pigs is 10 mg of active albendazole per kg of body weight, for horses - 7.5 mg / kg, for sheep and goats - 5 mg / kg, for fur-bearing animals - 15 mg / kg, for poultry - 10 mg / kg body weight. For mammals, a single administration of the drug is sufficient; for deworming birds, a double application of the drug is required.
Restrictions: the drug must not be used for deworming animals during the mating period, as well as pregnant or lactating females sharply weakened by infectious diseases of individuals.
Small and medium-sized cattle are allowed to be slaughtered for meat 10 days after the anthelmintic treatment, for large horned animals the limiting period is 14 days, for poultry - 5 days.
If the slaughter took place earlier than the specified period of restriction, then the meat is fed to other carnivores, or sent for processing into meat and bone meal. Milk from dairy breeds of animals and eggs from poultry are allowed to be eaten only after 4 days.
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