Nifuratel: Instructions For Use, Composition And Description

Nifuratel is a drug that is prescribed for infectious and inflammatory diseases of the genitourinary system and the digestive tract. Produced under various trade names, the most famous Nifuratel-based product is Macmiror. The drug is produced in the form of tablets and vaginal suppositories and can be used by people of any age.

The content of the article:

• 1 Brief description of the drug Nifuratel
• 2 What is Nifuratel
• 3 Composition of Nifuratel
• 4 Indications for use
• 5 Contraindications

• 6 Method of using Nifuratel tablets

  • 6.1 Inside.
  • 6.2 Urinary tract infections:
  • 6.3 Giardiasis:
  • 6.4 Intestinal amebiasis:
  • 6.5 Gastrointestinal infections associated with Helicobacter pylori:
• 7 Instruction for children
• 8 Candles Nifuratel
• 9 Side effects
• 10 Drug interactions
• 11 Overdose
• 12 Application during pregnancy and lactation

• 13 Preparations containing the substance "Nifuratel"

  13.1 Macmiror

• 14 Additional information
• 15 Cost and storage conditions
• 16 Reviews

Brief description of the drug Nifuratel

Nifuratel is a nitrofuran derivative that has antibacterial and antiseptic effects. This drug is often used for gastroduodenitis, genitourinary infections, intestinal infections, diseases of the upper gastrointestinal tract and enterocolitis. It can also be used to treat diseases of an infectious and inflammatory nature, provoked by bacteria. Nifuratel has a low toxicity and a high rate of absorption and excretion from the gastrointestinal tract, despite the fact that it is of synthetic origin.

What is Nifuratel

A nitrofuran derivative, Nifuratel is the generic name for a synthetic antibacterial agent. The McMiror medicine has this substance in its composition.

The drug has a pronounced antifungal, antibacterial and antiprotozoal effect, suppresses the vital activity of almost half of the known harmful cultures.

Macmiror is often used as an antiseptic for gynecological diseases. The active ingredient Nifuratel is obtained chemically in the Italian research laboratories Poli.

Composition of Nifuratel

• nifuratel - 200 mg;
• starch; polyethylene glycol 6000; talc; magnesium stearate; gelatin; gum arabic; sucrose; magnesium carbonate; titanium dioxide; E wax.

Indications for use

Often, after studying the clinical picture of the disease, in chronic or acute course, it is often recommended to use complex therapy instead of treatment with one drug.

In the treatment of vaginal infections, a course of topical restorative agents is carried out to maintain and improve the beneficial microflora. After entering the body, the drug is quickly spread by the blood and penetrates into almost all organs, destroys harmful microorganisms, negatively affects the ability to divide or multiply parasites.

Therapy with Macmiror is prescribed for such diseases (with acute or chronic form of the course):

• vulvovaginal infections (pathogens - Trichomonas, bacteria or fungi of the genus Candida);
• inflammatory diseases of the genitourinary system caused by infection (pyelonephritis, cystitis, urethritis);
• intestinal amebiasis;
• giardiasis;
• gastroduodenitis;
• enterocolitis;
• cholecystopancreatitis.

Contraindications

Hypersensitivity or individual intolerance to Nifuratel or its components.

Method of using Nifuratel tablets

Inside

Vaginal infections

• Adults: 1 tablet 3 times a day after meals for 7 days (both sexual pitners must take the drug).
• Children: the recommended dose is 10 mg / kg of body weight daily for 10 days.

Urinary tract infections:

Adults: depending on the severity of the disease, 3-6 tablets daily after meals for 7-14 days.

Children: the recommended dose is 30-60 mg / kg of body weight. The recommended dose should be taken in two divided doses.

Giardiasis:

• Adults: 2 tablets 2-3 times a day for 7 days.
• Children: the recommended dose is 15 mg / kg of body weight 2 times a day for 7 days

Intestinal amebiasis:

• Adults: 2 tablets 2-3 times a day for 10 days.
• Children: the recommended dose is 10 mg / kg of body weight 3 times a day.

Gastrointestinal tract infections associated with Helicobacter pylori:

• Adults: 2 tablets 2-3 times a day for 7 days.
• Children: the recommended dose is 15 mg / kg of body weight 2 times a day for 7 days.

A single dose for adults is 200-400 mg, for children - 10-30 mg / kg. The daily dose (taken in several doses) for adults is 600-1200 mg, for children - 10-30 mg / kg per day. The duration of treatment is determined individually by the attending physician.

Instruction for children

When taking Macmiror in tablet form, when calculating the required dosage, use the formula - 10-30 mg of active ingredient per 1 kg of the child's weight. Treatment of a child with Nifuratel is permissible only according to the direct indications of a doctor. This medication (tablets) can be used in children (over 6 years of age).

When taking Macmiror in tablet form, when calculating the required dosage, use the formula - 10-30 mg of active ingredient per 1 kg of the child's weight.

It is forbidden to use suppositories when treating a child, it is better to use McMiror cream for therapy (for this, a cannula is screwed onto the head of the syringe, which is located at the top of the rod). With a strong severity of the disease and a negative clinical picture of a small patient, the doctor has to adjust the dosage during therapy

Candles Nifuratel

Suppositories are recommended for vaginitis, trichomoniasis, candidiasis and other vulvovaginal diseases, ailments of the urinary tract. One suppository contains 500 mg of active ingredient. One candle is administered intravaginally, before bedtime, every day (course of 8 days). In case of using the cream, it is necessary to inject 2.5 grams of the substance into the vagina, 1 or 2 times a day. During menstruation, treatment is suspended, continued after the end of the critical days.

The suppository is inserted deep into the upper part of the vagina. In order to correctly insert the cream into the vagina, it is necessary to know the stages of correct carrying out of this manipulation: it is necessary to screw the graduated applicator onto the tube of cream; then we collect the required dose of ointment, gently pressing on the tube (there is a scale on the applicator that you can use to navigate); disconnect the applicator from the tube; we insert into the perineum and release the cream by pressing on the rod.

Side effects

• Skin lesions: rash;
• Local: itching.

Drug interactions

The substance Nifuratel is capable of enhancing the antifungal effect of nystatin, therefore they are often used together.

If you need local therapy of the urinary or genital tract, it is worth using suppositories or McMiror ointment (both active active ingredients are included in these preparations).

The medication mutually enhances the antichomoniasis effect, when taken simultaneously with tenonitrozole. There are no negative reviews about the result of the interaction of Nifuratel with other drugs.

Overdose

An overdose of Nifuratel is not described, the treatment is symptomatic.

Application during pregnancy and lactation

Given the ability of Nifuratel to penetrate the placental barrier, during pregnancy or lactation, this drug is approved for use only in cases where the benefit to the mother outweighs the potential risk to the fetus (developmental pathologies are not described, but there is a risk).

Since the active substance penetrates into breast milk, it is necessary to refuse breastfeeding for the period of therapy. Forms of topical application can be used during pregnancy with extreme caution, after all the necessary research.

Preparations containing the substance "Nifuratel"

Nifuratel is certified and approved for use in many European countries under different names (for example, Omnin, Macmiror, Inimur). The main analogue of Macmiror in tablets is Nifuratel.

In the catalogs of online stores, you can select and order drugs that do not contain Nifuratel and / or Nystatin, but have a similar spectrum of action and also have high efficiency at a low cost (Acylact, Furazolidone, Lactonorm, Colposptim).

It is not recommended to independently change or add drugs during treatment with Nifuratel.

McMiror

Nifuratel, an antimicrobial agent from the group of nitrofurans; has antiprotozoal, antifungal and antibacterial effects.

Spectrum of action includes: Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Shigella flexneri 2a, Shigella flexneri 6, Shigella sonnei, Salmonella typhi, Sermonella typhimurium., Salmonella spp. Enteritella., Citrobacter spp., Morganella spp., Rettgerella spp., Pragia fontium, Budvicia aquatica, Rachnella aquatilis and Acinetobacter spp., Other atypical enterobacteria, as well as protozoa (amoeba, lamblia); less active against Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa.

Nifuratel has high efficiency and low toxicity, which leads to a wide range of clinical applications. Shows high activity against both aerobic and anaerobic pathogens.

It is highly effective against Papiliobacter and Helicobacter pylori, gram-positive and gram-negative microorganisms: at a minimum inhibitory concentration (MIC) of 12.5–25 μg / ml, it inhibits 44.3 to 93.2% of cultures.

It is the drug of choice for the treatment of salmonellosis, shigellosis and other intestinal bacterial infections.

Active against Trichomonas vaginalis, highly active against Candida fungi. It is especially effective against metronidazole-resistant Helicobacter pylori strains. The obtained data indicate the high activity of nifuratel (in vitro and in vivo) against Atopobium vaginae, the main marker of bacterial vaginosis.

Additional Information

There are several useful recommendations for the use of Nifuratel, which help to obtain the most positive effect, to minimize the negative effect on the human body: regardless of the form of the medication, it is not recommended to use it while breastfeeding.

• After therapy, you can resume feeding the baby;
• during therapy, give up sexual intercourse, drinking alcoholic beverages;
• Nifuratel is not combined with many drugs, therefore, it is strictly forbidden to combine a medication with other drugs without the consent of a doctor;
• in the case of vulvo-vaginal infections, the woman's sexual partner needs to undergo a similar course of therapy, otherwise relapse cannot be avoided.

Cost and storage conditions

Nifuratel tablets can be purchased exclusively with a doctor's prescription, such a purchase condition applies to creams and to Macmiror complex ointments. If it is not possible to visit a real pharmacy and purchase a medicine, you can buy it in the online store at a good price. For a certain amount of purchase, the pharmacy staff will deliver the drug to the customer's home free of charge.

The price of Macmiror tablets (200 mg, twenty pieces) is about 850 rubles per pack. Store Nifuratel at a temperature of no more than 25 degrees Celsius for five years; after this period, it is prohibited to use the agent. Keep this medicine away from children.

Reviews

You have already learned what the instructions for use, the price of the drug "Nifuratel" are. Reviews of the medication are mostly positive. Consumers say that with proper use and dosage, recovery will always come.

If you neglect the scheme of use or independently adjust the dose of the drug, then the resistance of microorganisms to this active substance may develop. Always consult your doctor before using an antibacterial drug.

Find out more:

• Macmiror - indications, instructions for use and price
• Giardiasis (lamblia) in adults - signs, symptoms, treatment
• Trichomoniasis in women - causes, symptoms and treatment