Akrikhin - Instructions For Use, Indications And Dosage

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Akrikhin - Instructions For Use, Indications And Dosage
Akrikhin - Instructions For Use, Indications And Dosage

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Akrikhin is a broad-spectrum agent used to treat helminthic invasions, systemic lupus erythematosus, malaria, herpes, etc. The drug is usually well tolerated by patients and practically does not cause side effects. Before taking the drug, you should consult your doctor. Akrikhin is categorically contraindicated in persons with mental illness.

The content of the article:

  • 1 Drug Akrikhin
  • 2 Pharmacological action Akrikhin
  • 3 Indications and dosage
  • 4 Side effects when taking Akrikhin
  • 5 Contraindications
  • 6 Analogs (possible)

Akrikhin drug

Another name for the drug is known - mepacrine. What is Akrikhin? At first, the drug was synthesized from a dye to replace quinine as an antimalarial agent - it has the ability to destroy the intracellular structure of the malaria plasmodium, suppress activity and paralyze asexual organisms. The active element has a less toxic effect on the human body than quinine, but more effective antimalarial agents already exist.


Synonyms: Atabrine, Atebrin, Chemiochin, Chinacrine, Haffkinine, Hepacrin, Italcihne, Malaricida, Mecaprine, Mepacrine hydrochloride, Mepacrini hydrochloridum, Mepacrinum, Methochin, Methoquine, Palacrin, Palusin, Pentilen, Qurine

Now Akrikhin is a drug with wider application. The ability of the drug to reduce the sensitivity of the skin to ultraviolet radiation and have an anti-inflammatory effect is used to treat skin diseases. The active element of the drug has a destructive effect on parasitic organisms such as nematodes, flatworms and lamblia.

The drug received positive reviews in the fight against worms that live in the intestines (giardiasis). An effective remedy for the treatment of herpes. Good reviews were received when using the drug as an antipyretic agent. The drug is used as an immunosuppressant. The active ingredient of the drug mepacrine is a yellow crystalline powder, it has a bitter taste.

The substance is easily absorbed from the gastrointestinal tract into the bloodstream and accumulates in the liver, lungs, and spleen. The composition gently acts on the mucous membrane, does not cause irritation, it tends to stain the skin yellow. The decomposition of the substance occurs in the liver, and excretion from the body through the kidneys. About 10% of the drug is excreted per day, complete excretion ends after 10 days, after which the yellowness of the skin disappears.

The ability of the drug to accumulate in organs and tissues, slow excretion can lead to undesirable consequences, therefore, the drug can be used only on the recommendation and under the supervision of a doctor.

Pharmacological action Akrikhin

Akrikhin is rapidly absorbed from the gastrointestinal tract; after taking a therapeutic dose, the maximum concentration in the blood is observed after 2-3 hours; a high level of the drug in the blood is maintained for several hours. Akrikhin remains in the body for a long time.

It is excreted mainly by the kidneys, partially excreted in the bile, while in the duodenum it can be reabsorbed. Part of the drug taken is destroyed in the body. By the nature of the antimalarial action, Akrihin is close to Hingamin.

Due to the fact that acriquine is less active and, in addition, causes staining of the skin and mucous membranes, at present it is practically not used as an antimalarial agent. Akrikhin is also used as an antihelminthic agent and for the treatment of lupus erythematosus, cutaneous leishmaniasis (skin damage caused by an intracellular parasite transmitted to humans through a mosquito bite).

Indications and dosage


Malaria of all types, teniydoses (the general name for diseases / echinococcosis, alquveoccosis, teniasis, etc. / caused by parasitic worms related to nematodes), diphyllobothriasis (a disease caused by parasitic flatworms - tapeworms; the source of infection is fish), giardiasis (a disease caused by the simplest single-celled organisms parasitizing in the human small intestine), systemic lupus erythematosus.

As an antimalarial agent, Akrihin is taken orally after meals with plenty of water. The course is prescribed 1.5 g: on the 1st day, 0.3 g 2 times with an interval of 6 hours, on the 2-3-4th day - 0.3 g in 1 dose. On the 1st day of treatment, 0.3 g can be given, in this case, the course of treatment is extended by 1 day.

With a severe course of the disease, treatment can last up to 7 days. The age-specific daily doses of acriquine for malaria for children are the same as for bigumal. As an antihelminthic agent, Akrihin is used for cestodoses (a disease caused by a flatworm): invasions (introduction of animal parasites into the human body) by bovine tapeworm (teniidosis), dwarf tapeworm (hymenolepiasis), wide tapeworm (diphyllobothriasis).

On the eve and on the day of treatment, they take mashed food with limited fats, spicy and salty foods. At night, a saline laxative is prescribed. In the morning, they put a cleansing enema and give on an empty stomach the entire prescribed vine of akrihin (take 1-2 tablets every 5-10 minutes, wash down with water with the addition of sodium bicarbonate).


Akrihin is prescribed in the following doses: for adults -0.8 g; children 3-4 years old - 0.15-0.2 g, 5-6 years old - 0.25-0.3 g, 7-9 years old - 0.35-0.4 g, 10-12 years old - 0, 45 - 0.5 g, 13-14 years old - 0.6 g, 15-16 years old - 0.7 g. After 1 / 2-1 h after taking the last tablet, a saline laxative or a complex senna infusion is given. Breakfast is allowed 1-2 hours after taking a laxative.

If there was no stool within 3 hours after taking the laxative, an enema is given (for adults from 5 glasses of warm water, for children, respectively).

If the parasites come out without a head, another 1-2 enemas are given. With teniidosis and diphyllobothriasis, treatment is carried out once; with hymenolepiasis - 4 cycles of 3 days with an interval of 7 days. The drug is prescribed for adults at 0.3 g (in 2 doses after 20 minutes) per day on an empty stomach; on the 1st day of the first cycle, after 2 hours, a saline laxative is given.

When nausea and vomiting appear in the process of deworming (removal of worms / worms /) from the body, bed rest, a heating pad on the supraspinous area, and swallowing pieces of ice are recommended.

Recently, Akrihin has been used as an antihelminthic agent in combination with Fenasal, while the doses of Akrikhin can be reduced. In the treatment of giardiasis, Akrihin is taken 3 times a day 30 minutes before meals for 8 days in the following doses (per appointment): children under 2 years old - 0.012-0.015 g, 3 years old - 0.02-0.025 g, 4 years old - 0, 03 - 0.04 g, 5-7 years old - 0.05-0.075 g, 8-14 years old - 0.1 g, 14-16 years old and older - 0.1-0.15 g.


They are also prescribed in cycles: the first cycle is 5 days, the second is 3 days, the third is 3 days with an interval of 7 days between them. Higher doses of acriquine for adults: single - 0.3 g, daily - 0.6 g. In the initial forms of cutaneous leishmaniasis, 5% solution of acriquine (in 1% novocaine solution) is injected into the papule (into the shaped element of the rash, which is a cavityless formation protruding above the surface of the body), the injections are repeated after 3-4 weeks.

In case of lupus erythematosus, 0.1 g of Akrihin is prescribed 3 times a day in courses of 10 days with an interval between courses of 5-7 days; conduct 4-5 courses. Sometimes, in addition, lesions are injected with a 2-5% solution of akrikhin.

Side effects when taking Akrikhin

Akrikhin is usually well tolerated. The yellow coloration of the skin observed when taking Akrihin is harmless, but it can persist for several weeks and after the end of treatment.

In case of an overdose and in rare cases after taking the usual doses of acriquine, side reactions can be observed: “acriquine intoxication” - motor and speech excitement with loss of orientation, usually lasting several hours; “Akrikhinovy ​​psychosis”, accompanied by hallucinations (delusions, visions that acquire the character of reality), excitement or depression (a state of depression) and other phenomena that usually last no more than a week.

When neurological symptoms appear, Akrikhin is canceled, an abundant amount of fluid is injected, glucose and sedatives are prescribed.


Akrikhin is contraindicated in persons with mental illness, as well as in patients who previously had nervous disorders while taking the drug.


Relative contraindications: an unstable psyche, a sharp violation of renal excretory function, cholemia (increased blood levels of bile elements), a sharp staining of the skin due to prolonged use of akrikhin, delayed excretion of the drug in the urine. It is impossible to prescribe akriquine simultaneously with primaquine and quinoid or shortly before using these drugs.

Analogs (possible)

  • Quinine dihydrochloride (Chininidihydrochloridum)
  • Delagil
  • Metakelfin
  • Chinocidum (Chinocidum)
  • Bigumalum

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